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dc.contributor.authorSeixas, Gabriel Moura Alves-
dc.contributor.authorFreitas, Renata de Souza-
dc.contributor.authorFratelli, Caroline Ferreira-
dc.contributor.authorSilva, Calliandra Maria de Souza-
dc.contributor.authorLima, Luciano Ramos de-
dc.contributor.authorStival, Marina Morato-
dc.contributor.authorFunghetto, Silvana Schwerz-
dc.contributor.authorSilva, Izabel Cristina Rodrigues da-
dc.date.accessioned2024-06-06T14:58:41Z-
dc.date.available2024-06-06T14:58:41Z-
dc.date.issued2023-07-25-
dc.identifier.citationSEIXAS, Gabriel Moura Alves et al. MAOA uVNTR polymorphism influence on older adults diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension. Journal of Aging Research, v. 2023, art. ID 8538027, 7 p, 2023. DOI: https://doi.org/10.1155/2023/8538027.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/48167-
dc.language.isoengpt_BR
dc.publisherHindawipt_BR
dc.rightsAcesso Abertopt_BR
dc.titleMAOA uVNTR polymorphism influence on older adults diagnosed with Diabetes Mellitus/Systemic Arterial Hypertensionpt_BR
dc.typeArtigopt_BR
dc.subject.keywordPolimorfismo (Genética)pt_BR
dc.subject.keywordIdosospt_BR
dc.subject.keywordDiabetespt_BR
dc.subject.keywordHipertensão arterialpt_BR
dc.rights.license© 2023 Gabriel Moura Alves Seixas et al. !is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.pt_BR
dc.identifier.doihttps://doi.org/10.1155/2023/8538027pt_BR
dc.description.abstract1Background. Monoamine oxidase (MAO) is involved in several biological processes associated with well-being and mental health, and alterations in its function might directly impact various mental disorders. Some mental disorders concomitantly occur in individuals with clinical characteristics, such as substance abuse and diabetes. Objective. To analyze the functional MAOA uVNTR polymorphism genotype frequency in an older adult population with diabetes mellitus/arterial hypertension and associate this frequency with clinical characteristics impacting daily life. Methodology. Older adults diagnosed with diabetes mellitus, systemic arterial hypertension, or both (DM/SAH) were selected and had their MAOA gene genotyped for uVNTR polymorphism. The revised Beck Depression Inventory (BDI) and a questionnaire were also applied to determine their mental health and clinical characteristics. Results. The allelic variants detected among the participants were the 2R, 3R, 4R, and 3R/4R heterozygous genotypes. Genotypes solely containing the 3R allele had patients who marked yes for smoking and alcoholism, and only those with the 3R genotypes (female 3R/3R homozygote or male 3R ∗ hemizygote) were significant. Although not statistically significant, only 3R and 3R/4R genotypes presented cases of severe depression per the revised BDI interpretations. Conclusion. The MAOA uVNTR polymorphism’s low-activity 3R allele presence in an older adult population diagnosed with DM/SAH may represent a risk for developing substance use (alcohol and smoking) dependence.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0511-9452pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9064-0735pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6836-3583pt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilândia, Graduate Program in Health Sciences and Technologiespt_BR
dc.contributor.affiliationUniversity Center of Brasíliapt_BR
dc.contributor.affiliationCatholic University of Brasília, Graduate Program in Genomic Sciences and Biotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilândia, Graduate Program in Health Sciences and Technologiespt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilândiapt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilândiapt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilândiapt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilândiapt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilândiapt_BR
dc.description.unidadeFaculdade UnB Ceilândia (FCE)pt_BR
dc.description.unidadeCurso de Enfermagem (FCE-ENF)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências e Tecnologias em Saúdept_BR
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