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dc.contributor.authorPaiva, Maykon Jhuly Martins de-
dc.contributor.authorNascimento, Guilherme Nobre L do-
dc.contributor.authorDamasceno, Iangla Araújo de Melo-
dc.contributor.authorCunha, Lucas Nordhoff Barcelos-
dc.contributor.authorPimentel, Jeremias Emanoel de Sousa-
dc.contributor.authorSilva, Leda Terezinha Freitas e-
dc.contributor.authorCastro, Tayslane Dias-
dc.contributor.authorSilveira, Dâmaris-
dc.date.accessioned2024-06-07T14:28:20Z-
dc.date.available2024-06-07T14:28:20Z-
dc.date.issued2024-
dc.identifier.citationPAIVA, Maykon Jhuly Martins de et al. Antitumor evaluation of amaryllidaceae alkaloids on cancer cell lines: a literature review. Electronic Journal of General Medicine, [S. l.], v. 21, n. 1, em562, 2024. DOI: https://doi.org/10.29333/ejgm/14040. Disponível em: https://www.ejgm.co.uk/article/antitumor-evaluation-of-amaryllidaceae-alkaloids-on-cancer-cell-lines-a-literature-review-14040. Acesso em: 07 jun. 2024.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/48173-
dc.language.isoporpt_BR
dc.publisherModestumpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleAntitumor evaluation of amaryllidaceae alkaloids on cancer cell lines : a literature reviewpt_BR
dc.typeArtigopt_BR
dc.subject.keywordAmaryllidaceaept_BR
dc.subject.keywordAlcalóidespt_BR
dc.subject.keywordAtividade antitumoralpt_BR
dc.subject.keywordApoptosept_BR
dc.subject.keywordAngiogênesept_BR
dc.rights.license© 2024 by Author/s and Licensed by Modestum. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.pt_BR
dc.identifier.doihttps://doi.org/10.29333/ejgm/14040pt_BR
dc.description.abstract1Amaryllidaceae alkaloids have attracted significant attention in cancer research for their potential antitumor properties. To date, numerous studies have investigated the effects of these alkaloids on cancer cell lines, but a comprehensive synthesis of the existing evidence through a literature review is warranted. This article presents a comprehensive literature review aimed at evaluating the antitumor effects of amaryllidaceae alkaloids on various cancer cell lines and elucidating the underlying mechanisms of action. A search was conducted in major scientific databases, including Google Scholar, PubMed, Scopus, and Web of Science, to identify relevant studies published between 2013 and 2023. Studies that examined the antitumor effects of amaryllidaceae alkaloids on cancer cell lines were included in the review. Data were extracted, analyzed, and synthesized to provide an in-depth overview of the findings. The alkaloids exhibited potent cytotoxicity and suppressed cell proliferation in a concentration dependent manner. Mechanistic investigations unveiled that amaryllidaceae alkaloids induced apoptosis, cell cycle arrest, and hindered angiogenesis in cancer cells. Moreover, they demonstrated favorable selectivity towards cancer cells, sparing normal cells, suggesting potential as targeted therapies. This literature review consolidates and critically appraises the available evidence on the antitumor effects of amaryllidaceae alkaloids on cancer cell lines. The findings underscore their potential as promising candidates for further exploration in cancer therapeutics. Future preclinical and clinical studies are vital to advance their development and translation into effective anticancer drugs.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6228-4550pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4185-0872pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1281-8566pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0003-5826-6864pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0004-2163-1028pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1909-1286pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0002-3751-7081pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1851-5224pt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Sciences, Laboratory of Natural Productspt_BR
dc.contributor.affiliationUniversity of Gurupi, Paraíso do Tocantinspt_BR
dc.contributor.affiliationFederal University of Tocantins, Laboratory of Basic and Health Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Sciences, Laboratory of Natural Productspt_BR
dc.contributor.affiliationUniversity of Gurupi, Paraíso do Tocantinspt_BR
dc.contributor.affiliationUniversity of Gurupi, Paraíso do Tocantinspt_BR
dc.contributor.affiliationFaculdade de Palmaspt_BR
dc.contributor.affiliationFederal University of Tocantins, Laboratory of Basic and Health Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Sciences, Laboratory of Natural Productspt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências Farmacêuticaspt_BR
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