| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Carvalho, Amandda Évelin Silva de | - |
| dc.contributor.author | Oliveira, Nakaly Natiely de | - |
| dc.contributor.author | Machado, Julia Viana Lafetá | - |
| dc.contributor.author | Moreira, Daniel Carneiro | - |
| dc.contributor.author | Brand, Guilherme Dotto | - |
| dc.contributor.author | Leite, José Roberto de Souza de Almeida | - |
| dc.contributor.author | Plácido, Alexandra | - |
| dc.contributor.author | Eaton, Peter | - |
| dc.contributor.author | Araújo, Felipe Saldanha de | - |
| dc.date.accessioned | 2024-07-02T11:06:04Z | - |
| dc.date.available | 2024-07-02T11:06:04Z | - |
| dc.date.issued | 2023-07-01 | - |
| dc.identifier.citation | CARVALHO, Amandda Évelin Silva et al. The peptide salamandrin-I modulates components involved in Pyroptosis and induces cell death in human leukemia cell line HL-60. Pharmaceutics, [S. l.], 15, n. 7, 1864, 2023. DOI: https://doi.org/10.3390/pharmaceutics15071864. Disponível em: https://www.mdpi.com/1999-4923/15/7/1864. Acesso em: 02 jul. 2024. | pt_BR |
| dc.identifier.uri | http://repositorio2.unb.br/jspui/handle/10482/48493 | - |
| dc.language.iso | eng | pt_BR |
| dc.publisher | MDPI | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | The peptide salamandrin-I modulates components involved in Pyroptosis and induces cell death in human leukemia cell line HL-60 | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Peptídeos | pt_BR |
| dc.subject.keyword | Antioxidantes | pt_BR |
| dc.subject.keyword | Salamandra | pt_BR |
| dc.subject.keyword | Leucemia | pt_BR |
| dc.subject.keyword | Piroptose | pt_BR |
| dc.subject.keyword | Anfíbio | pt_BR |
| dc.rights.license | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | pt_BR |
| dc.identifier.doi | https://doi.org/10.3390/pharmaceutics15071864 | pt_BR |
| dc.description.abstract1 | Amphibian secretions have been extensively investigated for the production of bioactive molecules. Salamandrin-I is an antioxidant peptide, isolated from the skin secretion of the fire salamander, that has induced no toxicity in microglia or erythrocytes. Importantly, the administration of antioxidants may constitute an adequate therapeutic approach to cancer treatment. Here, with the purpose of better characterizing the therapeutic potential of salamandrin-I, we investigated whether this antioxidant peptide also exerts anticancer activity, using the human leukemia cell line HL-60 as a cancer model. Salamandrin-I treatment induced a significant reduction in HL-60 proliferation, which was accompanied by cell cycle arrest. Furthermore, the peptide-induced cell death showed a significant increase in the LDH release in HL-60 cells. The cellular toxicity exerted by salamandrin-I is possibly related to pyroptosis, since the HL-60 cells showed loss of mitochondrial membrane potential and hyperexpression of inflammasome components following the peptide treatment. This is the first demonstration of the anticancer potential of the salamandrin-I peptide. Such results are important, as they offer relevant insights into the field of cancer therapy and allow the design of future bioactive molecules using salamandrin-I as a template. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0003-1961-7281 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-1096-3236 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0003-1821-1992 | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Health Sciences, Laboratory of Hematology and Stem Cells (LHCT) | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Health Sciences, Laboratory of Hematology and Stem Cells (LHCT) | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Health Sciences, Laboratory of Hematology and Stem Cells (LHCT) | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Medicine, Research Center in Morphology and Applied Immunology, NuPMIA | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Institute of Chemistry | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Medicine, Research Center in Morphology and Applied Immunology, NuPMIA | pt_BR |
| dc.contributor.affiliation | University of Porto, Faculty of Sciences, Department of Chemistry and Biochemistry, LAQV/REQUIMTE | pt_BR |
| dc.contributor.affiliation | University of Lincoln, School of Chemistry, The Bridge | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Health Sciences, Laboratory of Hematology and Stem Cells (LHCT) | pt_BR |
| dc.description.unidade | Faculdade de Ciências da Saúde (FS) | pt_BR |
| dc.description.unidade | Departamento de Farmácia (FS FAR) | pt_BR |
| dc.description.unidade | Faculdade de Medicina (FM) | pt_BR |
| dc.description.unidade | Instituto de Química (IQ) | pt_BR |
| dc.description.ppg | Programa de Pós-Graduação em Patologia Molecular | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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