Skip navigation
Universidade de Brasília
Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/48494
Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
ARTIGO_InsightsMicroRNALandscape.pdf5,29 MBAdobe PDFVisualizar/Abrir
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorSantiago, Paula Beatriz-
dc.contributor.authorBentes, Kaio Luís da Silva-
dc.contributor.authorSilva, Waldeyr Mendes Cordeiro da-
dc.contributor.authorPraça, Yanna Reis-
dc.contributor.authorCharneau, Sébastien-
dc.contributor.authorChaouch, Soraya-
dc.contributor.authorGrellier, Philippe-
dc.contributor.authorFerraz, Marcos Antônio dos Santos Silva-
dc.contributor.authorBastos, Izabela Marques Dourado-
dc.contributor.authorSantana, Jaime Martins de-
dc.contributor.authorAraújo, Carla Nunes de-
dc.date.accessioned2024-07-02T11:53:11Z-
dc.date.available2024-07-02T11:53:11Z-
dc.date.issued2023-08-12-
dc.identifier.citationSANTIAGO, Paula Beatriz et al. Insights into the microRNA landscape of Rhodnius prolixus, a vector of Chagas disease. Scientific Reports, [S. l.], v. 13, art. n. 13120, 2023. DOI: https://doi.org/10.1038/s41598-023-40353-9. Disponível em: https://www.nature.com/articles/s41598-023-40353-9. Acesso em: 02 jul. 2024.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/48494-
dc.language.isoengpt_BR
dc.publisherNature Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleInsights into the microRNA landscape of Rhodnius prolixus, a vector of Chagas diseasept_BR
dc.typeArtigopt_BR
dc.subject.keywordVetorespt_BR
dc.subject.keywordChagas, Doença dept_BR
dc.subject.keywordMicroRNApt_BR
dc.subject.keywordTriatomíneospt_BR
dc.rights.licenseOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.pt_BR
dc.identifier.doihttps://doi.org/10.1038/s41598-023-40353-9pt_BR
dc.description.abstract1The growing interest in microRNAs (miRNAs) over recent years has led to their characterization in numerous organisms. However, there is currently a lack of data available on miRNAs from triatomine bugs (Reduviidae: Triatominae), which are the vectors of the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. A comprehensive understanding of the molecular biology of vectors provides new insights into insect-host interactions and insect control approaches, which are key methods to prevent disease incidence in endemic areas. In this work, we describe the miRNome profiles from gut, hemolymph, and salivary gland tissues of the Rhodnius prolixus triatomine. Small RNA sequencing data revealed abundant expression of miRNAs, along with tRNA- and rRNA-derived fragments. Fifty-two mature miRNAs, previously reported in Ecdysozoa, were identified, including 39 ubiquitously expressed in the three tissues. Additionally, 112, 73, and 78 novel miRNAs were predicted in the gut, hemolymph, and salivary glands, respectively. In silico prediction showed that the top eight most highly expressed miRNAs from salivary glands potentially target human blood-expressed genes, suggesting that R. prolixus may modulate the host’s gene expression at the bite site. This study provides the first characterization of miRNAs in a Triatominae species, shedding light on the role of these crucial regulatory molecules.pt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Pathogen-Host Interface Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Pathogen-Host Interface Laboratorypt_BR
dc.contributor.affiliationFederal Institute of Goiás, Formosa, Brazilpt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Pathogen-Host Interface Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistrypt_BR
dc.contributor.affiliationMuséum National d’Histoire Naturelle, UMR 7245 Molécules de Communication et Adaptation des Micro-organismespt_BR
dc.contributor.affiliationMuséum National d’Histoire Naturelle, UMR 7245 Molécules de Communication et Adaptation des Micro-organismespt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Scientific Illustration Centerpt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Pathogen-Host Interface Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Pathogen-Host Interface Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Pathogen-Host Interface Laboratorypt_BR
dc.contributor.affiliationFaculty of Ceilândia, University of Brasíliapt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
dc.description.unidadeNúcleo de Educação Científica (IB NECBio)pt_BR
dc.description.unidadeFaculdade UnB Ceilândia (FCE)-
dc.description.ppgPrograma de Pós-Graduação em Ciências Médicaspt_BR
Aparece nas coleções:Artigos publicados em periódicos e afins

Mostrar registro simples do item Visualizar estatísticas



Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.