Título:	Suppurative meningoencephalitis by Pseudomonas aeruginosa from direct extension of chronic otitis in a Gir cow
Autor(es):	Câmara, Antônio Carlos Lopes Sousa, Davi Emanuel Ribeiro de Mâcedo, Isabel Luana de Soares, Karoline Lacerda Borges, José Renato Junqueira Martins, Carlos Frederico Mesquita, Adriano Queiroz de Dutra, Valéria Castro, Márcio Botelho de
ORCID:	https://orcid.org/0000-0001-6895-7210 https://orcid.org/0000-0003-1237-0693 https://orcid.org/0000-0001-7327-9143 https://orcid.org/0000-0002-9202-8312 https://orcid.org/0000-0001-8551-0146 https://orcid.org/0000-0002-3996-0856
Afiliação do autor:	University of Brasília, College of Agronomy and Veterinary Medicine, Large Animal Veterinary Teaching Hospital University of Brasília, College of Agronomy and Veterinary Medicine, Veterinary Pathology Laboratory University of Brasília, College of Agronomy and Veterinary Medicine, Veterinary Pathology Laboratory University of Brasília, College of Agronomy and Veterinary Medicine, Veterinary Pathology Laboratory University of Brasília, College of Agronomy and Veterinary Medicine, Large Animal Veterinary Teaching Hospital Embrapa Cerrados, Centro de Tecnologia para Raças Zebuínas Leiteiras Embrapa Cerrados, Centro de Tecnologia para Raças Zebuínas Leiteiras Federal University of Mato Grosso, Veterinary Hospital, Laboratory of Veterinary Molecular Biology University of Brasília, College of Agronomy and Veterinary Medicine, Veterinary Pathology Laboratory
Assunto:	Bovino Sistema nervoso central Líquido cefalorraquidiano Infecções intracranianas supurativas
Data de publicação:	16-Jun-2023
Editora:	MDPI
Referência:	Suppurative meningoencephalitis by Pseudomonas aeruginosa from direct extension of chronic otitis in a Gir cow. Veterinary Sciences, [S. l.], v.10, n. 6, 398, 2023. DOI: https://doi.org/10.3390/vetsci10060398. Disponível em: https://www.mdpi.com/2306-7381/10/6/398. Acesso em: 02 jul.: 2024.
Abstract:	This paper aims to report clinical, laboratory and pathological features in a case of suppurative meningoencephalitis by P. aeruginosa from the direct extension of chronic otitis in a Gir cow. The cow was recumbent during physical examination, and neurological examination revealed depression, absence of left eyelid and auricular motor reflex, and hypotonic tongue. Hematology revealed hemoconcentration, leukocytosis by neutrophilia, and hyperfibrinogenemia. Cerebrospinal fluid was slightly turbid, and presented polymorphonuclear pleocytosis, and hyperproteinorrachia. Grossly, the skull floor showed a purulent green–yellow exudate that drained from the left inner ear to the cisterna magna. There was diffuse congestion of the telencephalon, and meninges showed severe hyperemia, moderate thickening, and opacity with the deposition of fibrinosuppurative material ventrally, extending to the cerebellum and brainstem. The left cerebellar hemisphere showed an approximately 1.5 cm in diameter liquefaction area surrounded by a hemorrhagic halo. Histologically, cerebellar, mesencephalic, thalamic, and brain base meninges were intensely thickened and showed severe suppurative inflammation and fibrin deposition. Small multifocal suppurative areas were observed in the cerebellum and brainstem, characterized by a necrotic core, a number of neutrophils, and Gram-negative intralesional bacillary myriads. Pure cultures of P. aeruginosa were obtained and identified in the suppurative CNS lesions, meninges, and inner ear samples. This report highlights an uncommon clinical evolution of secondary P. aeruginosa suppurative meningoencephalitis, probably triggered by recurrent parasitic otitis in an adult Gir cow. Veterinarians, practitioners, and farmers must be aware of the risk of CNS infections after unresolved media and inner otitis, especially in cattle breeds more prone to developing parasitic otitis, such as the Gir and Indubrasil breeds.
Unidade Acadêmica:	Faculdade de Agronomia e Medicina Veterinária (FAV)
Licença:	© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
DOI:	https://doi.org/10.3390/vetsci10060398
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