Título:	Persistent, new‑onset symptoms and mental health complaints in Long COVID in a Brazilian cohort of non‑hospitalized patients
Autor(es):	Almeida, Ricardo Titze de Cunha, Thaylise Ramalho da Silva, Letícia Dias dos Santos Ferreira, Clarisse Santos Silva, Caroline Pena Ribeiro, Adriana Pinheiro Santos Júnior, Agenor de Castro Moreira Brandão, Pedro Renato de Paula Silva, Andrezza Paula Brito Rocha, Márcia Cristina Oliveira da Xavier, Mary‑Ann Elvina Almeida, Simoneide Souza Titze de Shimizu, Helena Eri Rodrigues, Raimundo Nonato Delgado
ORCID:	https://orcid.org/0000-0002-5019-4742
Afiliação do autor:	University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes Armed Forces Hospital, Learning and Research Technical Board, Central Laboratory of Public Health of the Federal District, Brasília, Brazil University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes Federal District Strategic Health Management Institute, Brasília, Brazil University of Brasília, Central Institute of Sciences, Research Center for Major Themes Central Institute of Sciences, Technology for Gene Therapy Laboratory-FAV, University of Brasília University of Brasília, Central Institute of Sciences, Research Center for Major Themes Central Institute of Sciences, Technology for Gene Therapy Laboratory-FAV, University of Brasília Department of Collective Health, Research Center for Major Themes, University of Brasília University of Brasília, Central Institute of Sciences, Research Center for Major Themes
Assunto:	Memória - aspectos fisiológicos Depressão mental Sono - qualidade Saúde mental Covid-19
Data de publicação:	8-Fev-2022
Editora:	BMC
Referência:	ALMEIDA, Ricardo Titze de et al. Persistent, new‑onset symptoms and mental health complaints in Long COVID in a Brazilian cohort of non‑hospitalized patients. BMC Infectious Diseases, [S. l.], v. 22, 133, 2022. DOI: https://doi.org/10.1186/s12879-022-07065-3. Disponível em: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-022-07065-3. Acesso em: 03 jul. 2024.
Abstract:	Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections lead to acute- and chronic Long COVID (LC) symptoms. However, few studies have addressed LC sequelae on brain functions. This study was aimed to examine if acute symptoms of coronavirus disease 2019 (COVID-19) would persist during LC, and if memory problems would be correlated with sleep, depressive mood, or anxious complaints. Methods: Our work followed a cohort of 236 patients from two public hospitals of the Federal District in mid-west‑ern Brazil. Patients’ interviews checked for clinical symptoms during acute and LC (5–8 months after real-time reverse transcription polymerase chain reaction, RT-qPCR). Results: Most cases were non-hospitalized individuals (86.3%) with a median age of 41.2 years. While myalgia (50%), hyposmia (48.3%), and dysgeusia (45.8%) were prevalent symptoms in acute phase, fatigue (21.6%) followed by headache (19.1%) and myalgia (16.1%) commonly occurred during LC. In LC, 39.8% of individuals reported memory complaints, 36.9% felt anxious, 44.9% felt depressed, and 45.8% had sleep problems. Furthermore, memory complaints were associated with sleep problems (adjusted OR 3.206; 95% CI 1.723–6.030) and depressive feelings (adjusted OR 3.981; 95% CI 2.068–7.815). Conclusions: The SARS-CoV-2 infection leads to persistent symptoms during LC, in which memory problems may be associated with sleep and depressive complaints.
Unidade Acadêmica:	Faculdade de Agronomia e Medicina Veterinária (FAV) Faculdade de Ciências da Saúde (FS) Departamento de Saúde Coletiva (FS DSC) Instituto de Ciências Biológicas (IB) Faculdade de Medicina (FM)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências da Saúde Programa de Pós-Graduação em Nanociência e Nanobiotecnologia
Licença:	© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
DOI:	https://doi.org/10.1186/s12879-022-07065-3
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