Título:	Pharmacokinetics of curcumin delivered by nanoparticles and the relationship with antitumor efficacy : a systematic review
Autor(es):	Silvestre, Fernanda Altino Santos, Carolina Silva, Vitória R. P. Ombredane, Alicia Simalie Pinheiro, Willie Oliveira Andrade, Laise Rodrigues de Garcia, Mônica P. Pacheco, Thyago Joanitti, Graziella Anselmo Luz, Glécia Virgolino da Silva Carneiro, Marcella Lemos Brettas
ORCID:	https://orcid.org/0000-0002-8361-4854 https://orcid.org/0000-0002-5385-6174 https://orcid.org/0000-0002-6165-0969
Afiliação do autor:	University of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology University of Brasilia, Institute of Biological Sciences, Post-Graduate Program in Nanoscience and Nanobiotechnology University of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology University of Brasilia, Faculty of Gama, Post-Graduate Program in Biomedical Engineering University of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology University of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology University of Brasilia, Faculty of Health Sciences, Department of Nutrition University of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology University of Brasilia, Faculty of Ceilândia, Post-Graduate Program in Sciences and Technologies in Health University of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology University of Brasilia, Institute of Biological Sciences, Post-Graduate Program in Nanoscience and Nanobiotechnology University of Brasilia, Institute of Biological Sciences, Post-Graduate Program in Nanoscience and Nanobiotechnology University of Brasilia, Institute of Biological Sciences, Post-Graduate Program in Animal Biology University of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology University of Brasilia, Institute of Biological Sciences, Post-Graduate Program in Nanoscience and Nanobiotechnology University of Brasilia, Faculty of Ceilândia, Post-Graduate Program in Sciences and Technologies in Health University of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology University of Brasilia, Faculty of Gama, Post-Graduate Program in Biomedical Engineering University of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology University of Brasilia, Institute of Biological Sciences, Post-Graduate Program in Nanoscience and Nanobiotechnology University of Brasilia, Faculty of Gama, Post-Graduate Program in Biomedical Engineering
Assunto:	Curcumina Farmacocinética Nanopartículas Câncer
Data de publicação:	29-Jun-2023
Editora:	MDPI
Referência:	SILVESTRE, Fernanda et al. Pharmacokinetics of curcumin delivered by nanoparticles and the relationship with antitumor efficacy: a systematic review. Pharmaceuticals, [S. l.], v. 16, n. 7, 943, 2023. DOI: https://doi.org/10.3390/ph16070943. Disponível em: https://www.mdpi.com/1424-8247/16/7/943. Acesso em: 05 set. 2024.
Abstract:	Curcumin is a polyphenolic compound, derived from Curcuma longa, and it has sev- eral pharmacological effects such as antioxidant, anti-inflammatory, and antitumor. Although it is a pleiotropic molecule, curcumin’s free form, which is lipophilic, has low bioavailability and is rapidly metabolized, limiting its clinical use. With the advances in techniques for loading curcumin into nanostructures, it is possible to improve its bioavailability and extend its applications. In this review, we gather evidence about the comparison of the pharmacokinetics (biodistribution and bioavailability) between free curcumin (Cur) and nanostructured curcumin (Cur-NPs) and their re- spective relationships with antitumor efficacy. The search was performed in the following databases: Cochrane, LILACS, Embase, MEDLINE/Pubmed, Clinical Trials, BSV regional portal, ScienceDirect, Scopus, and Web of Science. The selected studies were based on studies that used High-Performance Liquid Chromatography (HPLC) as the pharmacokinetics evaluation method. Of the 345 studies initially pooled, 11 met the inclusion criteria and all included studies classified as high quality. In this search, a variety of nanoparticles used to deliver curcumin (polymeric, copolymeric, nanocrystals, nanovesicles, and nanosuspension) were found. Most Cur-NPs presented negative Zeta potential ranging from −25 mV to 12.7 mV, polydispersion index (PDI) ranging from 0.06 to 0.283, and hy- drodynamic diameter ranging from 30.47 to 550.1 nm. Selected studies adopted mainly oral and intravenous administrations. In the pharmacokinetics analysis, samples of plasma, liver, tumor, lung, brain, kidney, and spleen were evaluated. The administration of curcumin, in nanoparticle systems, resulted in a higher level of curcumin in tumors compared to free curcumin, leading to an improved antitumor effect. Thus, the use of nanoparticles can be a promising alternative for curcumin delivery since this improves its bioavailability.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Nutrição (FS NUT) Instituto de Ciências Biológicas (IB) Faculdade UnB Gama (FGA) Faculdade UnB Planaltina (FUP)
Programa de pós-graduação:	Programa de Pós-Graduação em Nanociência e Nanobiotecnologia Programa de Pós-Graduação em Engenharia Biomédica Programa de Pós-Graduação em Ciências e Tecnologias em Saúde Programa de Pós-Graduação em Biologia Animal
Licença:	Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
DOI:	https://doi.org/10.3390/ph16070943
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