| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Matos, Breno Noronha | - |
| dc.contributor.author | Lima, Ana Luiza | - |
| dc.contributor.author | Cardoso, Camila Oliveira | - |
| dc.contributor.author | Cunha Filho, Marcílio Sérgio Soares da | - |
| dc.contributor.author | Gratieri, Taís | - |
| dc.contributor.author | Gelfuso, Guilherme Martins | - |
| dc.date.accessioned | 2024-09-25T19:02:27Z | - |
| dc.date.available | 2024-09-25T19:02:27Z | - |
| dc.date.issued | 2023-09-19 | - |
| dc.identifier.citation | MATOS, Breno N. et al. Follicle-targeted delivery of betamethasone and minoxidil co-entrapped in polymeric and lipid nanoparticles for topical alopecia areata treatment. Pharmaceuticals. [S. l.], v. 16, n. 9, 19 set. 2023. DOI: https://doi.org/10.3390/ph16091322. Disponível em: https://www.mdpi.com/1424-8247/16/9/1322. Acesso em: 25 set. 2024. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/50450 | - |
| dc.language.iso | eng | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Follicle-targeted delivery of betamethasone and minoxidil co-entrapped in polymeric and lipid nanoparticles for topical alopecia areata treatment | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Alopécia | pt_BR |
| dc.subject.keyword | Nanotecnologia | pt_BR |
| dc.subject.keyword | Folículo capilar | pt_BR |
| dc.subject.keyword | Nanopartículas | pt_BR |
| dc.subject.keyword | Minoxidil | pt_BR |
| dc.subject.keyword | Alopecia areata | pt_BR |
| dc.subject.keyword | Betametasona | pt_BR |
| dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | pt_BR |
| dc.identifier.doi | https://doi.org/10.3390/ph16091322 | pt_BR |
| dc.description.abstract1 | Alopecia areata is managed with oral corticosteroids, which has known side effects for
patients. Given that a topical application of formulations containing a corticoid and a substance
controlling hair loss progression could reduce or eliminate such adverse effects and increase the
patient’s adherence to the treatment, this study prepares polymeric and lipidic nanoparticles (PNPs
and NLCs) to co-entrap minoxidil and betamethasone and compares the follicular drug delivery
provided by topical application of these nanoparticles. The prepared PNPs loaded 99.1 ± 13.0%
minoxidil and 70.2 ± 12.8% betamethasone, while the NLCs entrapped 99.4 ± 0.1 minoxidil and
80.7 ± 0.1% betamethasone. PNPs and NLCs presented diameters in the same range, varying from
414 ± 10 nm to 567 ± 30 nm. The thermal analysis revealed that the production conditions favor
the solubilization of the drugs in the nanoparticles, preserving their stability. In in vitro permeation
studies with porcine skin, PNPs provided a 2.6-fold increase in minoxidil penetration into the
follicular casts compared to the control and no remarkable difference in terms of betamethasone; in
contrast, NLCs provided a significant (specifically, a tenfold) increase in minoxidil penetration into
the hair follicles compared to the control, and they delivered higher concentrations of betamethasone
in hair follicles than both PNPs and the control. Neither PNPs nor NLCs promoted transdermal
permeation of the drugs to the receptor solution, which should favor a topical therapy. Furthermore,
both nanoparticles targeted approximately 50% of minoxidil delivery to the follicular casts and NLCs
targeted 74% of betamethasone delivery to the hair follicles. In conclusion, PNPs and NLCs are
promising drug delivery systems for enhancing follicular targeting of drugs, but NLCs showed
superior performance for lipophilic drugs. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0009-0007-9366-1260 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-2177-8941 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0003-3494-2111 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-9167-6852 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-6481-2364 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-1924-7885 | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences | pt_BR |
| dc.description.unidade | Faculdade de Ciências da Saúde (FS) | pt_BR |
| dc.description.unidade | Departamento de Farmácia (FS FAR) | - |
| dc.description.ppg | Programa de Pós-Graduação em Ciências da Saúde | - |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
|
