Título:	The newly discovered glymphatic system: the missing link between physical exercise and brain health?
Autor(es):	Olegário, Raphael Lopes Nóbrega, Otávio de Tolêdo Camargos, Einstein Francisco
Afiliação do autor:	University of Brasília, Faculty of Medicine, Graduate Program in Medical Sciences Brasília University Hospital, Geriatric Medicine Centre, Department of Clinical Medicine University of Brasília, Faculty of Medicine, Graduate Program in Medical Sciences Brasília University Hospital, Geriatric Medicine Centre, Department of Clinical Medicine University of Brasília, Faculty of Medicine, Graduate Program in Medical Sciences Brasília University Hospital, Geriatric Medicine Centre, Department of Clinical Medicine
Assunto:	Sistema glinfático Eercícios físicos Demência Doenças neurodegenerativas Cognição
Data de publicação:	15-Abr-2024
Editora:	Frontiers
Referência:	OLEGÁRIO, Raphael Lopes; NÓBREGA, Otávio de Tolêdo; CAMARGOS, Einstein Francisco. The newly discovered glymphatic system: the missing link between physical exercise and brain health?. Frontiers in Integrative Neuroscience, [S. l.], v. 18, 15 abr. 2024. DOI: https://doi.org/10.3389/fnint.2024.1349563. Disponível em: https://www.frontiersin.org/journals/integrative-neuroscience/articles/10.3389/fnint.2024.1349563/full. Acesso em:
Abstract:	Dementias are responsible for the most frequent neurodegenerative diseases and the seventh leading cause of death worldwide. As a result, there is a growing effort by the neuroscientific community to understand the physiopathology of neurodegenerative diseases, including how to alleviate the effects of the cognitive decline by means of non-pharmacological therapies (e.g., physical exercise). Studies have shown that exercise can improve aspects of brain health related to cognition. However, there still needs to be more knowledge regarding the mechanisms controlling these relationships, and a newly discovered cleansing system in the brain, named the glymphatic system, can be the missing link in this mechanism. The objective of this paper is to review recent findings regarding the potential impacts of physical exercise on the glymphatic system and its implications for the onset of neurodegenerative diseases. Additionally, considering the close interplay between exercise and sleep quality, we aim to explore how sleep patterns may intersect with exercise-induced effects on glymphatic function, further elucidating the complex relationship between lifestyle factors and brain health.
Unidade Acadêmica:	Instituto de Psicologia (IP) Departamento de Processos Psicológicos Básicos (IP PPB) Faculdade UnB Ceilândia (FCE) Colegiado de Bases Biológicas e da Saúde (FCE-BASES) Faculdade de Medicina (FM) Hospital Universitário de Brasília (HUB)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências do Comportamento
Licença:	© 2024 Olegario, Nóbrega and Camargos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI:	https://doi.org/10.3389/fnint.2024.1349563
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