Sorghum phytonutrients and their health benefits : a systematic review from cell to clinical trials

Oliveira, Lívia de Lacerda de; Figueiredo, Lúcio Flávio de Alencar

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Campo DC	Valor	Idioma
dc.contributor.author	Oliveira, Lívia de Lacerda de	-
dc.contributor.author	Figueiredo, Lúcio Flávio de Alencar	-
dc.date.accessioned	2024-10-20T21:11:31Z	-
dc.date.available	2024-10-20T21:11:31Z	-
dc.date.issued	2024-03-22	-
dc.identifier.citation	OLIVEIRA, Lívia de Lacerda de; FIGUEREDO, Lúcio Flávio de Alencar. Sorghum phytonutrients and their health benefits: a systematic review from cell to clinical trials. Journal of Food Science, 2024. DOI: https://doi.org/10.1111/1750-3841.17011.	pt_BR
dc.identifier.uri	http://repositorio.unb.br/handle/10482/50627	-
dc.language.iso	eng	pt_BR
dc.publisher	Wiley	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Sorghum phytonutrients and their health benefits : a systematic review from cell to clinical trials	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Anti-inflamatórios	pt_BR
dc.subject.keyword	Antioxidantes	pt_BR
dc.subject.keyword	Doenças crônicas	pt_BR
dc.subject.keyword	Sorgo	pt_BR
dc.identifier.doi	https://doi.org/10.1111/1750-3841.17011	pt_BR
dc.relation.publisherversion	https://ift.onlinelibrary.wiley.com/doi/full/10.1111/1750-3841.17011	pt_BR
dc.description.abstract1	Sorghum is key for global food security due to its genetic variability, resilience, and rich phytonutrient content, which are linked to numerous health bene fits. A systematic review assessed the health effects of sorghum by analyzing cell (n = 22), animal (n = 20), and human (n = 7) studies across antioxidant, anti-inflammatory, obesity, cancer, cardiovascular, and diabetes outcomes. This review, involving 42 papers and 177 researchers from 12 countries, collected data from sorghum accessions (acc) and significant effects. Studies used 68 identi fied and 8 unidentified sorghums, 57% red (n = 20), brown (n = 5), and black (n = 17) pericarp colors, and evaluated whole (n = 31), brans (n = 11), and decorti cated grains (n = 2). Colored sorghum, richer in phenolic compounds, especially 3-deoxyanthocyanins and tannins, inhibited cancer cell activities, including proliferation, tumor growth, and ROS activity, and promoted cell cycle arrest and apoptosis. Sorghum elevated HO1 and eNOS expression for cardiovascu lar, health-reduced platelet aggregation, and modulated platelet microparticles. They also suppressed inflammation markers and decreased lipid accumulation. Animal studies indicated sorghum’s potential across antioxidant capacity, can cer and inflammation mitigation, and lipid and glucose metabolism. Translating these findings to human scenarios requires caution, especially considering cell studies do not fully represent polyphenol metabolism. Human studies provided mixed results, indicating antioxidant and potential anti-inflammatory benefits and nuanced effects on glucose and lipid metabolism. The main risks of bias highlighted challenges in quantifying phytonutrients, identifying sorghum acc features, and lack of assessors blinding. Nonetheless, sorghum emerges as a promising functional food for countering chronic diseases in Western diets.	pt_BR
dc.contributor.affiliation	University of Brasília, Faculty of Health Sciences, Department of Nutrition	pt_BR
dc.contributor.affiliation	University of Brasília, Institute of Biology, Department of Botany	pt_BR
dc.description.unidade	Faculdade de Ciências da Saúde (FS)	pt_BR
dc.description.unidade	Departamento de Nutrição (FS NUT)	pt_BR
dc.description.unidade	Instituto de Ciências Biológicas (IB)	pt_BR
dc.description.unidade	Departamento de Botânica (IB BOT)	pt_BR
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