Evaluation of the potential use of cannabidiol in the treatment of cocaine use disorder : a systematic review

Rodrigues, Larissa Alencar; Caroba, Mariana Emanuele Silva; Taba, Fernando Kengy; Filev, Renato; Gallassi, Andrea Donatti

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Campo DC	Valor	Idioma
dc.contributor.author	Rodrigues, Larissa Alencar	-
dc.contributor.author	Caroba, Mariana Emanuele Silva	-
dc.contributor.author	Taba, Fernando Kengy	-
dc.contributor.author	Filev, Renato	-
dc.contributor.author	Gallassi, Andrea Donatti	-
dc.date.accessioned	2025-02-05T14:27:47Z	-
dc.date.available	2025-02-05T14:27:47Z	-
dc.date.issued	2020-07-22	-
dc.identifier.citation	RODRIGUES, Larissa Alencar et al. Evaluation of the potential use of cannabidiol in the treatment of cocaine use disorder: a systematic review. Pharmacology Biochemistry and Behavior, [S. l.], v. 196, 72982, 2020. DOI: https://doi.org/10.1016/j.pbb.2020.172982.	pt_BR
dc.identifier.uri	http://repositorio.unb.br/handle/10482/51470	-
dc.language.iso	eng	pt_BR
dc.publisher	Elsevier Inc.	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Evaluation of the potential use of cannabidiol in the treatment of cocaine use disorder : a systematic review	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Canabidiol	pt_BR
dc.subject.keyword	Farmacoterapia	pt_BR
dc.subject.keyword	Cacaína	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.pbb.2020.172982	pt_BR
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0091305720300307?via%3Dihub	pt_BR
dc.description.abstract1	Background: Cannabinoids may have an important therapeutic potential for the treatment of dependence on crack cocaine. Cannabidiol (CBD), in particular, has anxiolytic, antipsychotic and anticonvulsant properties and plays a role in regulating motivation circuitry and controlling sleep disorders. Several studies were performed evaluating CBD in experimental models for cocaine. This systematic review aims evaluate the potential use of CBD in the treatment of cocaine use disorder. Method: Five databases (Scielo; Medline/PubMed; PsycINFO; Cochrane Library; Virtual Health Library-VHL) were searched up to January 2020. Full-text reports published in English were included if they were experi mental studies that administered CBD to human and/or adult animals in use or with a history of crack/cocaine administration. The risk of bias of each study selected was appraised by two independent reviewers following the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) protocol. Major findings: Fifty-one studies were analyzed, and 14 were selected. No studies conducted with humans were found; only one clinical trial was ongoing. The results were grouped into the following categories: cocaine self administration, brain-stimulation reward, conditioned place preference, neuronal proliferation, anxiety, hepatic protection, anticonvulsant effect and locomotor sensitization response Only four studies had a low risk of bias. CBD promotes reduction on cocaine self-administration. Also, it interferes in cocaine induce brain reward sti mulation and dopamine release. CBD promotes alteration in contextual memory associated with cocaine and in the neuroadaptations, hepatotoxicity and seizures induced by cocaine. Conclusion: The evidence indicates that CBD is a promising adjunct therapy for the treatment of cocaine de pendence due to its effect on: cocaine reward effects, cocaine consumption, behavioral responses, anxiety, neuronal proliferation, hepatic protection and safety. Moreover, clinical trials are strongly required to determine whether the findings in animal models occur in humans diagnosed for cocaine or crack cocaine use disorder.	pt_BR
dc.contributor.affiliation	University of Brasília, Reference Center for Drugs and Associated Vulnerabilities	pt_BR
dc.contributor.affiliation	University of Brasília, Post-graduate Program of Health Sciences and Technology	pt_BR
dc.contributor.affiliation	University of Brasília, Reference Center for Drugs and Associated Vulnerabilities	pt_BR
dc.contributor.affiliation	University of Brasília, Reference Center for Drugs and Associated Vulnerabilities	pt_BR
dc.contributor.affiliation	Federal University of Sao Paulo, Department of Psychiatry and Medical Psychology, PROAD (Programa de Orientação e Atendimento a Dependentes)	-
dc.contributor.affiliation	University of Brasília, Reference Center for Drugs and Associated Vulnerabilities	-
dc.contributor.affiliation	University of Brasília, Post-graduate Program of Health Sciences and Technology	-
dc.description.unidade	Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia	pt_BR
dc.description.unidade	Curso de Terapia Ocupacional (FCTS-TER)	pt_BR
dc.description.ppg	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde	pt_BR
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