Título:	Increased prevalence of unstable HLA-C variants in HIV-1 rapid-progressor patients
Autor(es):	Stefani, Chiara Sangalli, Antonella Locatelli, Elena Federico, Tania Malerba, Giovanni Romanelli, Maria Grazia Argañaraz, Gustavo Adolfo Silva, Bosco Christiano Maciel da Silva, Alberto Jose Duarte da Casseb, Jorge Argañaraz, Enrique Roberto Ruggiero, Alessandra Zipeto, Donato
ORCID:	https://orcid.org/0000-0001-8705-8560 https://orcid.org/0000-0002-7360-1195 https://orcid.org/0000-0002-3883-7178 https://orcid.org/0000-0002-4553-2559 https://orcid.org/0000-0002-4359-7594 https://orcid.org/0000-0002-2168-4144
Afiliação do autor:	University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics University of Brasília, Faculty of Health Science, Lab of Molecular NeuroVirology University of São Paulo, Faculdade de Medicina FMUSP, Medical Investigation Laboratory Unit 56 (LIM/56) University of São Paulo, Faculdade de Medicina FMUSP, Medical Investigation Laboratory Unit 56 (LIM/56) University of São Paulo, Institute of Tropical Medicine, Faculty of Medicine University of Brasília, Faculty of Health Science, Lab of Molecular NeuroVirology University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics
Assunto:	AIDS (Doença) HIV-1 Antígenos
Data de publicação:	27-Nov-2022
Editora:	MDPI
Referência:	STEFANI, Chiara et al. Increased prevalence of unstable HLA-C variants in HIV-1 rapid-progressor patients. International Journal Molecular Sciences, [S. l.], v. 23, n. 23, 14852, 2022. DOI: https://doi.org/10.3390/ijms232314852. Disponível em: https://www.mdpi.com/1422-0067/23/23/14852. Acesso em: 25 fev. 2025.
Abstract:	HIV-1 infection in the absence of treatment results in progression toward AIDS. Host genetic factors play a role in HIV-1 pathogenesis, but complete knowledge is not yet available. Since less-expressed HLA-C variants are associated with poor HIV-1 control and unstable HLA-C variants are associated with higher HIV-1 infectivity, we investigated whether there was a correlation between the different stages of HIV-1 progression and the presence of specific HLA-C allotypes. HLA-C genotyping was performed using allele-specific PCR by analyzing a treatment-naïve cohort of 96 HIV-1-infected patients from multicentric cohorts in the USA, Canada, and Brazil. HIV-1-positive subjects were classified according to their different disease progression status as progressors (Ps, n = 48), long-term non-progressors (LTNPs, n = 37), and elite controllers (ECs, n = 11). HLA-C variants were classified as stable or unstable according to their binding stability to β2-microglobulin/peptide complex. Our results showed a significant correlation between rapid progression to AIDS and the presence of two or one unstable HLA-C variants (p-value: 0.0078, p-value: 0.0143, respectively). These findings strongly suggest a link between unstable HLA-C variants both at genotype and at allele levels and rapid progression to AIDS. This work provides further insights into the impact of host genetic factors on AIDS progression.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS FAR)
Licença:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
DOI:	https://doi.org/10.3390/ijms232314852
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