Título:	Cannabidiol affects MK-801-induced changes in the PPI Learned Response of Capuchin Monkeys (Sapajus spp.)
Autor(es):	Saletti, Patrícia Grandizoli Maior, Rafael Plakoudi Souto Barros, Marília Nishijo, Hisao Tomaz, Carlos Alberto Bezerra
Assunto:	Canabidiol Esquizofrenia Macaco
Data de publicação:	27-Fev-2017
Editora:	Frontiers
Referência:	SALETTI, Patrícia Grandizoli et al. Cannabidiol affects MK-801-induced changes in the PPI Learned Response of Capuchin Monkeys (Sapajus spp.). Frontiers in Pharmacology, v. 8, Article 93, 27 fev. 2017. Disponível em: <http://journal.frontiersin.org/article/10.3389/fphar.2017.00093/full>. Acesso em: 4 jul. 2017. doi: http://journal.frontiersin.org/article/10.3389/fphar.2017.00093/full.
Abstract:	There are several lines of evidence indicating a possible therapeutic action of cannabidiol (CBD) in schizophrenia treatment. Studies with rodents have demonstrated that CBD reverses MK-801 effects in prepulse inhibition (PPI) disruption, which may indicate that CBD acts by improving sensorimotor gating deficits. In the present study, we investigated the effects of CBD on a PPI learned response of capuchin monkeys (Sapajus spp.). A total of seven monkeys were employed in this study. In Experiment 1, we evaluated the CBD (doses of 15, 30, 60 mg/kg, i.p.) effects on PPI. In Experiment 2, the effects of sub-chronic MK-801 (0.02 mg/kg, i.m.) on PPI were challenged by a CBD pre-treatment. No changes in PPI response were observed after CBD-alone administration. However, MK-801 increased the PPI response of our animals. CBD pre-treatment blocked the PPI increase induced by MK-801. Our findings suggest that CBD’s reversal of the MK-801 effects on PPI is unlikely to stem from a direct involvement on sensorimotor mechanisms, but may possibly reflect its anxiolytic properties.
Licença:	Copyright © 2017 Saletti, Maior, Barros, Nishijo and Tomaz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Fonte: <http://journal.frontiersin.org/article/10.3389/fphar.2017.00093/full>. Acesso em: 4 jul. 2017.
DOI:	https://dx.doi.org/10.3389/fphar.2017.00093
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