Título:	The role of T cell subsets and cytokines in the regulation of intracellular bacterial infection
Autor(es):	Oliveira, S. C. Harms, J. S. Rech, E. L. Rodarte, Renato Santos Bocca, Anamélia Lorenzetti Goes, A. M. Splitter, G. A.
Assunto:	Imunologia veterinária Bacterioses Brucelose Citocinas
Data de publicação:	Jan-1998
Editora:	Associação Brasileira de Divulgação Científica
Referência:	OLIVEIRA, S. C. et al. The role of T cell subsets and cytokines in the regulation of intracellular bacterial infection. Brazilian Journal of Medical and Biological Research, v. 31, n. 1, p. 77-84, jan. 1998. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100010>. Acesso em: 10 jul 2017. doi: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100010.
Abstract:	Cellular immune responses are a critical part of the host's defense against intracellular bacterial infections. Immunity to Brucella abortus crucially depends on antigen-specific T cell-mediated activation of macrophages, which are the major effectors of cell-mediated killing of this organism. T lymphocytes that proliferate in response to B. abortus were characterized for phenotype and cytokine activity. Human, murine, and bovine T lymphocytes exhibited a type 1 cytokine profile, suggesting an analogous immune response in these different hosts. In vivo protection afforded by a particular cell type is dependent on the antigen presented and the mechanism of antigen presentation. Studies using MHC class I and class II knockout mice infected with B. abortus have demonstrated that protective immunity to brucellosis is especially dependent on CD8+ T cells. To target MHC class I presentation we transfected ex vivo a murine macrophage cell line with B. abortus genes and adoptively transferred them to BALB/c mice. These transgenic macrophage clones induced partial protection in mice against experimental brucellosis. Knowing the cells required for protection, vaccines can be designed to activate the protective T cell subset. Lastly, as a new strategy for priming a specific class I-restricted T cell response in vivo, we used genetic immunization by particle bombardment-mediated gene transfer.
Licença:	Brazilian Journal of Medical and Biological Research - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (Attribution 4.0 International (CC BY 4.0)). Fonte: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100010>. Acesso em: 10 jul 2017.
DOI:	https://dx.doi.org/10.1590/S0100-879X1998000100010
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