Titre:	Analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk amazon amerindian populations
Auteur(s):	Guimarães, Maria de Nazaré Klautau D’Ascenção, Renata Caldart, Fabiana A. Grisolia, Cesar Koppe Souza, Jurandir R. de Barbosa, Antonio C. Cordeiro, Célia M. T. Ferrari, Iris
Assunto::	Indígenas Polimorfismo (Genética) Mercúrio (Hg)
Date de publication:	déc-2005
Editeur:	Sociedade Brasileira de Genética
Référence bibliographique:	GUIMARÃES, Maria de Nazaré Klautau et al. Analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk amazon amerindian populations. Genetics and Molecular Biology, São Paulo, v. 28, n. 4, p. 827-832, dez. 2005. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000500027&lng=en&nrm=iso>. Acesso em: 24 out. 2017. doi: http://dx.doi.org/10.1590/S1415-47572005000500027.
Abstract:	We investigated Individual differences in susceptibility to methylmercury (MeHg) contamination and its relationship with polymorphisms of the detoxifying enzyme glutathione S-transferase (GST). In Brazil, some Amerindian tribes from the Amazon region have an increased level of mercury in their hair. Samples of hair and blood were taken from inhabitants of two villages in the Kayabi and Munduruku Amerindian communities to investigate mercury levels in association with genetic polymorphism of GSTs. Other molecular biological markers were also studied, such as hemoglobin, haptoglobin and glucose 6-phosphate dehydrogenase (G-6-PDH). Higher levels of mercury contamination were found in the Kayabi villagers, who had a null genotype (GSTM1 0/0, also denominated GSTM1 null) frequency of 26%, than in the Munduruku villagers, for which the null genotype frequency was 0%. Individuals with the GSTM1 null phenotype had higher concentrations of mercury in their hair than individuals with GSTM1+/+ phenotypes (F = 21.51, p < 0.0001). No association with other markers studied was observed. This study suggests that GSTM1 may be involved in the biotransformation of mercury in humans.
Licença::	Genetics and Molecular Biology - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. (CC BY NC). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000500027&lng=en&nrm=iso. Acesso em: 24 out. 2017.
DOI:	http://dx.doi.org/10.1590/S1415-47572005000500027
Collection(s) :	Artigos publicados em periódicos e afins

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