| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Britto, Constança | pt_BR |
| dc.contributor.author | Silveira, Celeste Aída Nogueira | pt_BR |
| dc.contributor.author | Cardoso, Maria Angelica | pt_BR |
| dc.contributor.author | Marques, Patricia | pt_BR |
| dc.contributor.author | Ostermayer, Alejandro Luquetti | pt_BR |
| dc.contributor.author | Macêdo, Vanize de Oliveira | pt_BR |
| dc.contributor.author | Fernandes, Octavio | pt_BR |
| dc.date.accessioned | 2017-12-07T04:33:49Z | - |
| dc.date.available | 2017-12-07T04:33:49Z | - |
| dc.date.issued | 2001-08 | pt_BR |
| dc.identifier.citation | BRITTO, Constança et al. Parasite persistence in treated chagasic patients revealed by xenodiagnosis and polymerase chain reaction. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 6, p. 823-826, ago. 2001. DOI: https://doi.org/10.1590/S0074-02762001000600014. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000600014&lng=en&nrm=iso. Acesso em: 19 mar. 2021. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/25702 | - |
| dc.language.iso | en | pt_BR |
| dc.publisher | Instituto Oswaldo Cruz, Ministério da Saúde | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Parasite persistence in treated chagasic patients revealed by xenodiagnosis and polymerase chain reaction | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Trypanosoma cruzi | pt_BR |
| dc.subject.keyword | DNA de cinetoplasto | pt_BR |
| dc.subject.keyword | Chagas, Doença de | - |
| dc.subject.keyword | PCR | - |
| dc.subject.keyword | Tratamento | - |
| dc.rights.license | Memórias do Instituto Oswaldo Cruz - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000600014&lng=en&tlng=en. Acesso em: 19 mar. 2021. | - |
| dc.identifier.doi | https://dx.doi.org/10.1590/S0074-02762001000600014 | pt_BR |
| dc.description.abstract1 | Polymerase chain reaction (PCR) was compared with xenodiagnosis performed 20 years after trypanocidal chemotherapy to investigate parasite clearance. Eighty-five seropositive individuals for Chagas disease presenting a positive xenodiagnosis were treated with specific drugs; 37 in the acute phase and 48 in the chronic phase. Fifteen chronic assymptomatic patients received a placebo. Treatment in the acute phase led to PCR negative results in 73% of the cases, while xenodiagnosis was negative in 86%. In the chronic phase, PCR was negative in 65% of the patients and 83% led to xenodiagnosis negative results. Regarding the untreated group (placebo), 73% gave negative results by xenodiagnosis, of which 36% were positive by PCR. Individuals that were considered seronegative (n=10), presented unequivocally negative results in the PCR demonstrating the elimination of parasite DNA. Seventeen individuals had their antibodies titers decreased to such a level that the final results were considered as doubtful and 16 of them presented negative PCR. The molecular method represents a clear advantage over conventional techniques to demonstrate persistent infections in Chagas disease patients that underwent chemotherapy. | - |
| dc.description.unidade | Faculdade de Medicina (FMD) | - |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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