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dc.contributor.authorRomero, Gustavo Adolfo Sierrapt_BR
dc.contributor.authorFlores, Érico Marlon de Moraespt_BR
dc.contributor.authorNoronha, Elza Ferreirapt_BR
dc.contributor.authorMacêdo, Vanize de Oliveirapt_BR
dc.date.accessioned2017-12-07T04:37:35Z-
dc.date.available2017-12-07T04:37:35Z-
dc.date.issued2003-01pt_BR
dc.identifier.citationROMERO, Gustavo Adolfo Sierra et al. High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 1, p. 145-149, jan. 2003. DOI: https://doi.org/10.1590/S0074-02762003000100019. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019&lng=en&nrm=iso. Acesso em: 04 dez. 2020.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/25981-
dc.language.isoenpt_BR
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúdept_BR
dc.rightsAcesso Abertopt_BR
dc.titleHigh frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controlspt_BR
dc.typeArtigopt_BR
dc.subject.keywordMedicamentos - análisept_BR
dc.subject.keywordMetais pesadospt_BR
dc.subject.keywordLeishmaniose cutâneapt_BR
dc.subject.keywordChumbopt_BR
dc.subject.keywordArsêniopt_BR
dc.subject.keywordToxidadept_BR
dc.subject.keywordEfeitos adversos-
dc.rights.licenseMemórias do Instituto Oswaldo Cruz - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019&lng=en&tlng=en. Acesso em: 04 dez. 2020.-
dc.identifier.doihttps://dx.doi.org/10.1590/S0074-02762003000100019pt_BR
dc.description.abstract1We analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals in an endemic area of the State of Bahia, Brazil. Group A patients were treated in 2000 with the drug produced by Eurofarma Laboratórios Ltda., São Paulo, Brazil (lot A) and group B patients were treated in 1996 with the reference drug produced by Rhodia Farma Ltda., São Paulo, Brazil (lot B). We observed an unusual higher frequency of skin reactions in group A patients. However, all type of adverse events observed in group A were also observed in group B. The physico-chemical analysis of these lots revealed that lot A had lower pH and higher concentration of total and trivalent antimony, lead, cadmium, and arsenic. Our findings suggest that the skin reactions could be attributed to heavy metal contamination of lot A.-
dc.description.unidadeFaculdade de Medicina (FMD)-
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