| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Romero, Gustavo Adolfo Sierra | pt_BR |
| dc.contributor.author | Flores, Érico Marlon de Moraes | pt_BR |
| dc.contributor.author | Noronha, Elza Ferreira | pt_BR |
| dc.contributor.author | Macêdo, Vanize de Oliveira | pt_BR |
| dc.date.accessioned | 2017-12-07T04:37:35Z | - |
| dc.date.available | 2017-12-07T04:37:35Z | - |
| dc.date.issued | 2003-01 | pt_BR |
| dc.identifier.citation | ROMERO, Gustavo Adolfo Sierra et al. High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 1, p. 145-149, jan. 2003. DOI: https://doi.org/10.1590/S0074-02762003000100019. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019&lng=en&nrm=iso. Acesso em: 04 dez. 2020. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/25981 | - |
| dc.language.iso | en | pt_BR |
| dc.publisher | Instituto Oswaldo Cruz, Ministério da Saúde | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Medicamentos - análise | pt_BR |
| dc.subject.keyword | Metais pesados | pt_BR |
| dc.subject.keyword | Leishmaniose cutânea | pt_BR |
| dc.subject.keyword | Chumbo | pt_BR |
| dc.subject.keyword | Arsênio | pt_BR |
| dc.subject.keyword | Toxidade | pt_BR |
| dc.subject.keyword | Efeitos adversos | - |
| dc.rights.license | Memórias do Instituto Oswaldo Cruz - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019&lng=en&tlng=en. Acesso em: 04 dez. 2020. | - |
| dc.identifier.doi | https://dx.doi.org/10.1590/S0074-02762003000100019 | pt_BR |
| dc.description.abstract1 | We analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals in an endemic area of the State of Bahia, Brazil. Group A patients were treated in 2000 with the drug produced by Eurofarma Laboratórios Ltda., São Paulo, Brazil (lot A) and group B patients were treated in 1996 with the reference drug produced by Rhodia Farma Ltda., São Paulo, Brazil (lot B). We observed an unusual higher frequency of skin reactions in group A patients. However, all type of adverse events observed in group A were also observed in group B. The physico-chemical analysis of these lots revealed that lot A had lower pH and higher concentration of total and trivalent antimony, lead, cadmium, and arsenic. Our findings suggest that the skin reactions could be attributed to heavy metal contamination of lot A. | - |
| dc.description.unidade | Faculdade de Medicina (FMD) | - |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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