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Título: High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls
Autor(es): Romero, Gustavo Adolfo Sierra
Flores, Érico Marlon de Moraes
Noronha, Elza Ferreira
Macêdo, Vanize de Oliveira
Assunto: Medicamentos - análise
Metais pesados
Leishmaniose cutânea
Chumbo
Arsênio
Toxidade
Efeitos adversos
Data de publicação: Jan-2003
Editora: Instituto Oswaldo Cruz, Ministério da Saúde
Referência: ROMERO, Gustavo Adolfo Sierra et al. High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 1, p. 145-149, jan. 2003. DOI: https://doi.org/10.1590/S0074-02762003000100019. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019&lng=en&nrm=iso. Acesso em: 04 dez. 2020.
Abstract: We analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals in an endemic area of the State of Bahia, Brazil. Group A patients were treated in 2000 with the drug produced by Eurofarma Laboratórios Ltda., São Paulo, Brazil (lot A) and group B patients were treated in 1996 with the reference drug produced by Rhodia Farma Ltda., São Paulo, Brazil (lot B). We observed an unusual higher frequency of skin reactions in group A patients. However, all type of adverse events observed in group A were also observed in group B. The physico-chemical analysis of these lots revealed that lot A had lower pH and higher concentration of total and trivalent antimony, lead, cadmium, and arsenic. Our findings suggest that the skin reactions could be attributed to heavy metal contamination of lot A.
Unidade Acadêmica: Faculdade de Medicina (FMD)
Licença: Memórias do Instituto Oswaldo Cruz - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019&lng=en&tlng=en. Acesso em: 04 dez. 2020.
DOI: https://dx.doi.org/10.1590/S0074-02762003000100019
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