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Title: CCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestry
Authors: Carvalho, Mônica W.P.
Leboute, Ana P.M.
Oliveira, Silviene F.
Sousa, Sandra M.B.
Klautau-Guimarães, Maria de Nazaré
Simões, Aguinaldo L.
Assunto:: Ccr5
Polimorfismo genético
Populações brasileiras de origem afrosubsaariana
Marcador étnico-groespecífico
Issue Date: 2004
Publisher: Sociedade Brasileira de Genética
Citation: Genet. Mol. Biol.,v.27,n.3,p.321-325,2004
Abstract: This study reports the frequencies of the CCR5D32 mutation of the beta-chemokine 5 gene and discusses the possible effects of past and recent gene flow in three quilombo remnants (Brazilians communities with anthropological African ancestry whose ancestors were escaped slaves): Rio das Rãs, Mocambo, and São Gonçalo in the northeastern region of Brazil. The CCR5D32 allele frequency of the Mocambo population was significantly higher (5.6%) than that found in the Rio das Rãs (1%) and São Gonçalo (0.9%) populations. These differences may reflect different proportions of parental populations in the founders individuals, a founder-effect and/or different histories of inter-ethnic contact. The frequency of the CCR5D32 allele in the Mocambo sample is similar to that found in those urban Brazilian populations which have a large amount of European genetic input, indicating a European contribution to the gene pool of this population and suggesting that, perhaps since its foundation, Mocambo has had a high level of admixture or experienced a founder-effect.
metadata.dc.description.unidade: Em processamento
DOI: https://dx.doi.org/10.1590/S1415-47572004000300002
Appears in Collections:Artigos publicados em periódicos e afins

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