Title:	Plasmodium vivax malaria : related factors to severity in the State of Maranhão, Brazil
Authors:	Raposo, Camila Cristina Bastos Silva Santos, João Barberino Santos, Gisele Maria Campelo dos Gonçalves, Eloísa da Graça do Rosário Silva, Antônio Rafael da
Assunto::	Malária - Brasil Gravidade Plasmodium vivax Malária - Maranhão - epidemiologia
Issue Date:	Feb-2013
Publisher:	Sociedade Brasileira de Medicina Tropical - SBMT
Citation:	RAPOSO, Camila Cristina Bastos Silva et al. Plasmodium vivax malaria: related factors to severity in the State of Maranhão, Brazil. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba, v. 46, n. 1, p. 67-72, jan./fev. 2013. DOI: https://doi.org/10.1590/0037-868212382013. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000100067&lng=en&tlng=en. Acesso em: 08 set. 2020.
Abstract:	INTRODUCTION: Malaria caused by Plasmodium vivax species has shown signs of severity, recorded with increasing frequency in the medical literature. This study aimed to characterize the signs of severe malaria by Plasmodium vivax in the State of Maranhão, Brazil. METHODS: A descriptive cohort study of patients assisted in the field and a historical and concurrent study of a series of cases among hospitalized patients were undertaken to identify the clinical and laboratory signs of severity. RESULTS: A total of 153 patients were included in the study, 13 of whom were hospitalized. Males made up the majority, numbering 103 (67.3%). The age of the patients ranged from 10 to 70 years, 92.2% were natives of the State of Maranhão, and 65% of the patients had had malaria before. The average time elapsed between symptom onset and diagnosis among outpatients was three days, while among hospitalized patients this average reached 15.5 days, a statistically significant difference (p=0.001). The parasitemia ranged from 500 to 10,000 parasites/µl in 92.8% of cases. The clinical and laboratory manifestations of severity were vomiting and diarrhea, jaundice, drowsiness, mental confusion, seizures, loss of consciousness, agitation, bleeding, pale skin, coughing and dyspnea, thrombocytopenia, anemia, elevation of nitrogenous compounds, and elevated transaminases and bilirubin. CONCLUSIONS: The monitoring of malaria patients with Plasmodium vivax showed the possibility of aggravation, the intensity of which varied in different circumstances, especially the interval time between falling ill and diagnostic confirmation.
metadata.dc.description.unidade:	Faculdade de Medicina (FMD)
Licença::	Revista da Sociedade Brasileira de Medicina Tropical - (CC BY-NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000100067&lng=en&tlng=en. Acesso em: 08 set. 2020.
DOI:	https://dx.doi.org/10.1590/0037-868212382013
Appears in Collections:	Artigos publicados em periódicos e afins

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