Title:	The effect of carbon dioxide therapy on composite graft survival
Authors:	Durães, Eliana Ferreira Ribeiro Durães, Leonardo de Castro Carneiro, Fabiana Pirani Lino Júnior, Ruy de Souza Sousa, João Batista de
Assunto::	Cura Dióxido de carbono Coelho
Issue Date:	Aug-2013
Publisher:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Citation:	DURAES, Eliana Ferreira Ribeiro et al. The effect of carbon dioxide therapy on composite graft survival. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 8, p. 589-593, ago. 2013. DOI: https://doi.org/10.1590/S0102-86502013000800006. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000800006&lng=en&nrm=iso. Acesso em: 04 dez. 2020.
Abstract:	PURPOSE: To investigate the effect of carboxytherapy in auricular composite grafts in rabbits. METHODS: An experimental study was conducted using 20 rabbits randomly assigned to a treatment group of carboxytherapy or a control group of saline solution. In each ear, a circular graft with 1.5 cm or 2 cm of diameter was amputated and reattached. Animals underwent carbon dioxide or saline injection four times during the experiment. We analyzed clinical evolution of the animals, grafts survival, histopathology features and histomorphometry of collagen. RESULTS:The treated group had a significantly lower weight gain (p=0.038). Histopathology was not significantly different between groups. There was an increase in amount of collagen in 2 cm grafts submitted to carbon dioxide therapy (p=0.003). Carboxytherapy didn't influence graft survival rate for 1.5 cm grafts or 2 cm grafts (p=0.567 and p=0.777, respectively). CONCLUSIONS:Carbon dioxide therapy increased the amount of collagen in 2 cm grafts. CO2 was not significantly different from saline infusion on composite grafts survival, but this study suggests that there is a mechanical effect caused by distension which favored graft survival.
metadata.dc.description.unidade:	Faculdade de Medicina (FMD)
Licença::	Acta Cirúrgica Brasileira - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000800006&lng=en&tlng=en. Acesso em: 04 dez. 2020.
DOI:	https://dx.doi.org/10.1590/S0102-86502013000800006
Appears in Collections:	Artigos publicados em periódicos e afins

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