| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Vieira, Michele Juliane | pt_BR |
| dc.contributor.author | Perosa, Sandra Regina | pt_BR |
| dc.contributor.author | Argañaraz, Gustavo Adolfo | pt_BR |
| dc.contributor.author | Silva Junior, José Antônio | pt_BR |
| dc.contributor.author | Cavalheiro, Esper Abrão | pt_BR |
| dc.contributor.author | Naffah-Mazzacoratti, Maria da Graça | pt_BR |
| dc.date.accessioned | 2017-12-07T05:09:09Z | - |
| dc.date.available | 2017-12-07T05:09:09Z | - |
| dc.date.issued | 2014 | pt_BR |
| dc.identifier.citation | VIEIRA, Michele Juliane et al. Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus. Clinics, São Paulo, v. 69, n. 9, p. 621-626, set. 2014. DOI: http://dx.doi.org/10.6061/clinics/2014(09)08. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000900621&lng=en&nrm=iso. Acesso em: 30 out. 2019. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/29416 | - |
| dc.language.iso | en | pt_BR |
| dc.publisher | Faculdade de Medicina / USP | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Anti-inflamatórios | pt_BR |
| dc.subject.keyword | Inflamação | pt_BR |
| dc.subject.keyword | Epilepsia | pt_BR |
| dc.rights.license | Clinics - (CC BY NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000900621&lng=en&nrm=iso&tlng=en. Acesso em: 30 out. 2019. | - |
| dc.identifier.doi | https://dx.doi.org/10.6061/clinics/2014(09)08 | pt_BR |
| dc.description.abstract1 | OBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules. METHOD: The hippocampus of rats submitted to pilocarpine-induced long-lasting status epilepticus was analyzed to determine the expression of inflammatory molecules with RT-PCR and immunohistochemistry. RESULTS: Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin. CONCLUSIONS: These data show that low doses of indomethacin could be employed to minimize inflammation during long-lasting status epilepticus. | - |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
|
