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ARTIGO_ IndomethacinDownregulateLevels.pdf2,39 MBAdobe PDFVisualizar/Abrir
Título: Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus
Autor(es): Vieira, Michele Juliane
Perosa, Sandra Regina
Argañaraz, Gustavo Adolfo
Silva Junior, José Antônio
Cavalheiro, Esper Abrão
Naffah-Mazzacoratti, Maria da Graça
Assunto: Anti-inflamatórios
Inflamação
Epilepsia
Data de publicação: 2014
Editora: Faculdade de Medicina / USP
Referência: VIEIRA, Michele Juliane et al. Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus. Clinics, São Paulo, v. 69, n. 9, p. 621-626, set. 2014. DOI: http://dx.doi.org/10.6061/clinics/2014(09)08. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000900621&lng=en&nrm=iso. Acesso em: 30 out. 2019. 
Abstract: OBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules. METHOD: The hippocampus of rats submitted to pilocarpine-induced long-lasting status epilepticus was analyzed to determine the expression of inflammatory molecules with RT-PCR and immunohistochemistry. RESULTS: Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin. CONCLUSIONS: These data show that low doses of indomethacin could be employed to minimize inflammation during long-lasting status epilepticus.
Licença: Clinics - (CC BY NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000900621&lng=en&nrm=iso&tlng=en. Acesso em: 30 out. 2019.
DOI: https://dx.doi.org/10.6061/clinics/2014(09)08
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