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dc.contributor.authorGomes, Ciro Martinspt_BR
dc.contributor.authorMazin, Suleimy Cristinapt_BR
dc.contributor.authorSantos, Elisa Raphael dospt_BR
dc.contributor.authorCesetti, Mariana Vicentept_BR
dc.contributor.authorBächtold, Guilherme Albergaria Brízidapt_BR
dc.contributor.authorCordeiro, João Henrique de Freitaspt_BR
dc.contributor.authorTheodoro, Fabrício Claudino Estrela Terrapt_BR
dc.contributor.authorDamasco, Fabiana dos Santospt_BR
dc.contributor.authorCarranza, Sebastián Andrés Vernalpt_BR
dc.contributor.authorSantos, Adriana de Oliveirapt_BR
dc.contributor.authorRoselino, Ana Mariapt_BR
dc.contributor.authorSampaio, Raimunda Nonata Ribeiropt_BR
dc.date.accessioned2017-12-07T05:11:37Z-
dc.date.available2017-12-07T05:11:37Z-
dc.date.issued2015-04pt_BR
dc.identifier.citationGOMES, Ciro Martins et al. Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 2, p. 157-165, abr. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200157&lng=en&nrm=iso>. Acesso em: 9 maio 2018. Epub Mar 31, 2015. doi: http://dx.doi.org/10.1590/0074-02760140280.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/29536-
dc.language.isoenpt_BR
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúdept_BR
dc.rightsAcesso Abertopt_BR
dc.titleAccuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction : systematic literature review and meta-analysispt_BR
dc.typeArtigopt_BR
dc.subject.keywordLeishmaniosept_BR
dc.subject.keywordDiagnósticopt_BR
dc.rights.licenseMemórias do Instituto Oswaldo Cruz - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200157&lng=en&nrm=iso. Acesso em: 9 maio 2018.-
dc.identifier.doihttp://dx.doi.org/10.1590/0074-02760140280pt_BR
dc.description.abstract1The diagnosis of mucocutaneous leishmaniasis (MCL) is hampered by the absence of a gold standard. An accurate diagnosis is essential because of the high toxicity of the medications for the disease. This study aimed to assess the ability of polymerase chain reaction (PCR) to identify MCL and to compare these results with clinical research recently published by the authors. A systematic literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA Statement was performed using comprehensive search criteria and communication with the authors. A meta-analysis considering the estimates of the univariate and bivariate models was performed. Specificity near 100% was common among the papers. The primary reason for accuracy differences was sensitivity. The meta-analysis, which was only possible for PCR samples of lesion fragments, revealed a sensitivity of 71% [95% confidence interval (CI) = 0.59; 0.81] and a specificity of 93% (95% CI = 0.83; 0.98) in the bivariate model. The search for measures that could increase the sensitivity of PCR should be encouraged. The quality of the collected material and the optimisation of the amplification of genetic material should be prioritised.-
dc.description.unidadeFaculdade de Medicina (FM)-
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