| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Santana, Washington Macedo de | pt_BR |
| dc.contributor.author | Sousa, Dircilei Nascimento de | pt_BR |
| dc.contributor.author | Ferreira, Vania Maria Moraes | pt_BR |
| dc.contributor.author | Duarte, Wagner Rodrigues | pt_BR |
| dc.date.accessioned | 2017-12-07T05:18:20Z | - |
| dc.date.available | 2017-12-07T05:18:20Z | - |
| dc.date.issued | 2016-05 | pt_BR |
| dc.identifier.citation | SANTANA, Washington Macedo de et al. Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects. Acta Cirurgica Brasileira, São Paulo, v. 31, n. 5, p. 300-307, maio 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000500300&lng=en&nrm=iso>. Acesso em: 5 mar. 2018. doi: http://dx.doi.org/10.1590/S0102-865020160050000002. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/30182 | - |
| dc.language.iso | en | pt_BR |
| dc.publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Cálcio | pt_BR |
| dc.subject.keyword | Ossos - crescimento | pt_BR |
| dc.subject.keyword | Ratos | pt_BR |
| dc.rights.license | Acta Cirurgica Brasileira - This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000500300&lng=en&nrm=iso. Acesso em: 6 mar. 2018. | - |
| dc.identifier.doi | http://dx.doi.org/10.1590/S0102-865020160050000002 | pt_BR |
| dc.description.abstract1 | Purpose: to investigate the effects of locally applied simvastatin plus biphasic calcium phosphate (BoneCeramic(r)) or collagen sponge on bone formation in critical-sized bone defects. Methods: thirty defects of 5mm in diameter were created bilaterally with a trephine bur in the calvariae of fifteen Wistar rats. The defects were divided into five groups: group 1 - control, no treatment; group 2 (BoneCeramic(r)); group 3 (BoneCeramic(r) + 0.1mg simvastatin); group 4 (collagen sponge); and group 5 (collagen sponge + 0.1mg simvastatin). After eight weeks the animals were euthanized and their calvariae were histologically processed. Hematoxylin and eosin-stained sections were subjected to histological and histomorphometrical analyses. The area of newly formed bone was calculated and compared between groups. Results: the greater amount of a bone-like tissue was formed around the carrier in group 3 (BoneCeramic(r) + 0.1mg simvastatin) followed by group 2 (BoneCeramic(r)), and almost no bone was formed in the other groups. Group 3 was significantly different compared to group 2, and both groups were significantly different compared to the other groups. Conclusion: simvastatin combined with BoneCeramic(r) induced significantly greater amounts of newly formed bone and has great potential for the healing of bone defects. | - |
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