Title:	Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects
Authors:	Santana, Washington Macedo de Sousa, Dircilei Nascimento de Ferreira, Vania Maria Moraes Duarte, Wagner Rodrigues
Assunto::	Cálcio Ossos - crescimento Ratos
Issue Date:	May-2016
Publisher:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Citation:	SANTANA, Washington Macedo de et al. Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects. Acta Cirurgica Brasileira, São Paulo, v. 31, n. 5, p. 300-307, maio 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000500300&lng=en&nrm=iso>. Acesso em: 5 mar. 2018. doi: http://dx.doi.org/10.1590/S0102-865020160050000002.
Abstract:	Purpose: to investigate the effects of locally applied simvastatin plus biphasic calcium phosphate (BoneCeramic(r)) or collagen sponge on bone formation in critical-sized bone defects. Methods: thirty defects of 5mm in diameter were created bilaterally with a trephine bur in the calvariae of fifteen Wistar rats. The defects were divided into five groups: group 1 - control, no treatment; group 2 (BoneCeramic(r)); group 3 (BoneCeramic(r) + 0.1mg simvastatin); group 4 (collagen sponge); and group 5 (collagen sponge + 0.1mg simvastatin). After eight weeks the animals were euthanized and their calvariae were histologically processed. Hematoxylin and eosin-stained sections were subjected to histological and histomorphometrical analyses. The area of newly formed bone was calculated and compared between groups. Results: the greater amount of a bone-like tissue was formed around the carrier in group 3 (BoneCeramic(r) + 0.1mg simvastatin) followed by group 2 (BoneCeramic(r)), and almost no bone was formed in the other groups. Group 3 was significantly different compared to group 2, and both groups were significantly different compared to the other groups. Conclusion: simvastatin combined with BoneCeramic(r) induced significantly greater amounts of newly formed bone and has great potential for the healing of bone defects.
Licença::	Acta Cirurgica Brasileira - This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000500300&lng=en&nrm=iso. Acesso em: 6 mar. 2018.
DOI:	http://dx.doi.org/10.1590/S0102-865020160050000002
Appears in Collections:	Artigos publicados em periódicos e afins

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