Title:	Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus : implications for field studies
Authors:	Cruz, Helena Medina Scalioni, Leticia de Paula Paula, Vanessa Salete de Miguel, Juliana Custódio Ó, Kycia Maria Rodrigues do Milagres, Flavio Augusto Pádua Cruz, Marcelo Santos Bastos, Francisco Inácio Flores, Priscila Pollo Leal, Erotildes Motta-Castro, Ana Rita Coimbra Lewis-Ximenez, Lia Laura Lampe, Elisabeth Villar, Livia Melo
Assunto::	Hepatite B Anticorpos
Issue Date:	Mar-2017
Publisher:	Instituto Oswaldo Cruz, Ministério da Saúde
Citation:	CRUZ, Helena Medina et al. Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus: implications for field studies. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 3, p. 209-213, mar. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000300209&lng=en&nrm=iso>. Acesso em: 22 fev. 2018. Epub Jan 30, 2017. doi: http://dx.doi.org/10.1590/0074-02760160394.
Abstract:	Rapid tests (RTs) can be used as an alternative method for the conventional diagnosis of hepatitis B virus (HBV). This study aims to evaluate antibodies to HBsAg (anti-HBs) and antibodies to HBeAg (anti-HBe) RTs under different Brazilian settings. The following three groups were included: GI: viral hepatitis outpatient services; GII: low resource areas; and GIII: crack users and beauticians. Imuno-rápido anti-HBsAg™ and Imuno-rápido anti-HBeAg™ RTs were evaluated and showed specificities greater than 95% in all groups. The sensitivity values to anti-HBs were 50.38%, 51.05% and 46.73% and the sensitivity values to anti-HBe were 76.99%, 10.34% and 11.76% in the GI, GII and GIII groups, respectively. The assays had a low sensitivity and high specificity, which indicated their use for screening in regions endemic for HBV.
metadata.dc.description.unidade:	Faculdade de Medicina (FMD)
Licença::	Memórias do Instituto Oswaldo Cruz - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000300209&lng=en&nrm=iso. Acesso em: 22 fev. 2018.
DOI:	http://dx.doi.org/10.1590/0074-02760160394
Appears in Collections:	Artigos publicados em periódicos e afins

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