| Élément Dublin Core | Valeur | Langue |
|---|
| dc.contributor.author | Pavon, Lorena Favaro | - |
| dc.contributor.author | Sibov, Tatiana Tais | - |
| dc.contributor.author | Oliveira, Daniela Mara de | - |
| dc.contributor.author | Marti, Luciana C. | - |
| dc.contributor.author | Cabral, Francisco Romero | - |
| dc.contributor.author | Souza, Jean Gabriel de | - |
| dc.contributor.author | Boufleur, Pamela | - |
| dc.contributor.author | Malheiros, Suzana M. F. | - |
| dc.contributor.author | Neto, Manuel A. de Paiva | - |
| dc.contributor.author | Cruz, Edgard Ferreira da | - |
| dc.contributor.author | Tavassi, Ana Marisa Chudzinski | - |
| dc.contributor.author | Cavalheiro, Sérgio | - |
| dc.date.accessioned | 2018-12-11T11:01:30Z | - |
| dc.date.available | 2018-12-11T11:01:30Z | - |
| dc.date.issued | 2016-05 | - |
| dc.identifier.citation | PAVON, Lorena Favaro et al. Mesenchymal stem cell-like properties of CD133+ glioblastoma initiating cells. Oncotarget, Nova York, v. 7, p. 40546-40557, maio 2016. DOI: https://doi.org/10.18632/oncotarget.9658. Disponível em: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=9658&path[]=41659. Acesso em: 11 dez. 2018. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/33159 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | Impact Journals | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Mesenchymal stem cell-like properties of CD133+ glioblastoma initiating cells | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Neurosferas | pt_BR |
| dc.subject.keyword | Glicoproteínas | pt_BR |
| dc.subject.keyword | Células-tronco | pt_BR |
| dc.subject.keyword | Microscopia eletrônica | pt_BR |
| dc.subject.keyword | Tumores | pt_BR |
| dc.rights.license | Oncotarget - All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License (CC BY). Fonte: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=9658&path[]=41659. Acesso em: 11 dez. 2018. | pt_BR |
| dc.identifier.doi | https://doi.org/10.18632/oncotarget.9658 | pt_BR |
| dc.description.abstract1 | Glioblastoma is composed of dividing tumor cells, stromal cells and tumor initiating CD133+ cells. Recent reports have discussed the origin of the glioblastoma CD133+ cells and their function in the tumor microenvironment. The present work sought to investigate the multipotent and mesenchymal properties of primary highly purified human CD133+ glioblastoma-initiating cells. To accomplish this aim, we used the following approaches: i) generation of tumor subspheres of CD133+ selected cells from primary cell cultures of glioblastoma; ii) analysis of the expression of pluripotency stem cell markers and mesenchymal stem cell (MSC) markers in the CD133+ glioblastoma-initiating cells; iii) side-by-side ultrastructural characterization of the CD133+ glioblastoma cells, MSC and CD133+ hematopoietic stem cells isolated from human umbilical cord blood (UCB); iv) assessment of adipogenic differentiation of CD133+ glioblastoma cells to test their MSC-like in vitro differentiation ability; and v) use of an orthotopic glioblastoma xenograft model in the absence of immune suppression. We found that the CD133+ glioblastoma cells expressed both the pluripotency stem cell markers (Nanog, Mush-1 and SSEA-3) and MSC markers. In addition, the CD133+ cells were able to differentiate into adipocyte-like cells. Transmission electron microscopy (TEM) demonstrated that the CD133+ glioblastoma-initiating cells had ultrastructural features similar to those of undifferentiated MSCs. In addition, when administered in vivo to non-immunocompromised animals, the CD133+ cells were also able to mimic the phenotype of the original patient’s tumor. In summary, we showed that the CD133+ glioblastoma cells express molecular signatures of MSCs, neural stem cells and pluripotent stem cells, thus possibly enabling differentiation into both neural and mesodermal cell types. | pt_BR |
| Collection(s) : | Artigos publicados em periódicos e afins
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