http://repositorio.unb.br/handle/10482/33450| Fichier | Taille | Format | |
|---|---|---|---|
| ARTIGO_SynthesisExpansionBicyclic.pdf | 159,35 kB | Adobe PDF | Voir/Ouvrir |
| Titre: | Synthesis and expansion of bicyclic enol ether: a probable precursor for the synthesis of macrolide (±)-pyrenophorin |
| Auteur(s): | Costa, Maísa Borges Martins, Marcos P. Araújo, Hugo Clemente de Resck, Inês Sabioni |
| Assunto:: | Química orgânica Antibióticos |
| Date de publication: | 2018 |
| Editeur: | Sociedade Brasileira de Química |
| Référence bibliographique: | COSTA, Maísa B. et al. Synthesis and expansion of bicyclic enol ether: a probable precursor for the synthesis of macrolide (±)-pyrenophorin. Journal of the Brazilian Chemical Society, São Paulo, v. 29, n. 1, p. 74-78, jan. 2018. DOI: http://dx.doi.org/10.21577/0103-5053.20170114. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000100074&lng=en&nrm=iso. Acesso em: 16 maio 2019. |
| Résumé: | A convenient procedure for the synthesis and expansion of bicyclic rings has been developed for the production of probable precursors of non-racemic pyrenophorin, an antibiotic dilactone. The major highlight for this new synthetic methodology came from the use of a readily available reagent of easy manipulation, 9-oxabicyclo[3.3.1]nonane-2,6-diol, for the preparation of the bicyclic intermediate, which sequentially was subjected to oxidative cleavage with butyl nitrite resulted in an isomeric mixture, a dioximedilactone and diisoxazoledilactone. |
| Licença:: | (CC BY) - This is an open-access article distributed under the terms of the Creative Commons Attribution License. |
| DOI: | http://dx.doi.org/10.21577/0103-5053.20170114 |
| Collection(s) : | Artigos publicados em periódicos e afins |
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