Title:	Stress conditions in the host induce persister cells and influence biofilm formation by Staphylococcus epidermidis RP62A
Authors:	Fraiha, Rafael Ovando Pereira, Ana Paula Ramos Brito, Eliana da Costa Alvarenga Borges, Clayton Luiz Parente, Ana Flávia Alves Perdomo, Renata Trentin Macedo, Maria Ligia Rodrigues Weber, Simone Schneider
metadata.dc.identifier.orcid:	http://orcid.org/0000-0002-4181-142X
Assunto::	Persistência Inanição Virulência (Microbiologia)
Issue Date:	2019
Publisher:	Sociedade Brasileira de Medicina Tropical - SBMT
Citation:	FRAIHA, Rafael Ovando et al. Stress conditions in the host induce persister cells and influence biofilm formation by Staphylococcus epidermidis RP62A. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba, v. 52, e20180001, 2019. DOI: https://doi.org/10.1590/0037-8682-0001-2018. Disponível em: http://scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100608. Acesso em: 23 jan. 2020.
Abstract:	INTRODUCTION: Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival. METHODS: Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host. RESULTS: Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in pH. In contrast, iron limitation led to decreased surface-adherent biomass, accompanied by an increase medium acidification and lactate levels. Interestingly, iron starvation and hypoxia induced persister cells in planktonic culture. CONCLUSIONS: These findings highlight the role of host stress in the virulence of S. epidermidis.
Licença::	OPEN ACCESS - https://creativecommons.org/licenses/by/4.0/ (CC BY)
DOI:	https://doi.org/10.1590/0037-8682-0001-2018
Appears in Collections:	Artigos publicados em periódicos e afins

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