http://repositorio.unb.br/handle/10482/4026
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ARTIGO_HyperlipidemiaRelatedUseHIV.pdf | 363,39 kB | Adobe PDF | Visualizar/Abrir |
Título: | Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate |
Autor(es): | Caramelli, Bruno Bernoche, Claudia Y.S.M. de Sartori, Ana M.C Spósito, Andrei Carvalho Santos, Raul D. Monachini, Maristela C. Strabelli, Tania Uip, Davi |
Assunto: | Colesterol Lipídios HIV - infecção Triglicerídios |
Data de publicação: | Dez-2001 |
Referência: | CARAMELLI, Bruno. Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate. Brazilian Journal of Infectious Diseases, Salvador, v. 5, n. 6, p. 332-338, dec. 2001. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600007&Ing=en&nrm=iso>. Acesso em 15 mar. 2010. |
Resumo: | Hyperlipidemia has been frequently recorded as a side effect of treating HIV patients with protease inhibitors (PI). This study was initiated to analyze the modifications on blood lipids in HIV-patients receiving PI and the safety and efficacy of the treatment with fenofibrate. Total (TC) and HDL-cholesterol, triglycerides (TG), and CD4+ T-cell counts were measured in 30 HAART-naive patients (Group I) before and after PI introduction. In a second phase of the study, the effects of fenofibrate on lipids, CPK, CD4+, and viral load were determined in 13 patients (Group II) with elevated TC or TG. In Group I, 60% of the patients showed TC or TG elevations. Average increments of 31% and 146% in TC and TG respectively (p<0.0006 and p<0.0001) were observed. In Group II, fenofibrate treatment was associated with decrements of 6.6% (TC) and 45.7% (TG) (p=0.07 and 0.0002) and no modifications on CPK, CD4+, and viral load. In conclusion, hyperlipidemia is common during the treatment of HIV with protease inhibitors, and fenofibrate appears to be an effective and safe choice for its treatment. |
Unidade Acadêmica: | Faculdade de Medicina (FMD) |
Informações adicionais: | 7 f. |
Aparece nas coleções: | Artigos publicados em periódicos e afins |
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