Title:	A comprehensive systematic review of leishmaniasis in patients undergoing drug-induced immunosuppression for the treatment of dermatological, rheumatological and gastroenterological diseases
Authors:	Kurizky, Patricia Shu Marianelli, Fernanda Ferraço Cesetti, Mariana Vicente Damiani, Giovanni Sampaio, Raimunda Nonata Ribeiro Gonçalves, Lais Mitsue Tanaka Sousa, Carlos Augusto Felipe de Martins, Sofia Sales Vernal, Sebastian Mota, Licia Maria Henrique da Gomes, Ciro Martins
metadata.dc.identifier.orcid:	http://orcid.org/0000-0002-3069-6884
Assunto::	Imunossupressão Leishmaniose Revisão sistemática Tratamento
Issue Date:	2020
Publisher:	Instituto de Medicina Tropical
Citation:	KURIZKY, Patrícia Shu et al. A comprehensive systematic review of leishmaniasis in patients undergoing drug-induced immunosuppression for the treatment of dermatological, rheumatological and gastroenterological diseases. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 62, e28, 2020. DOI: https://doi.org/10.1590/s1678-9946202062028. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652020000100217&lng=en&nrm=iso. Acesso em: 05 abr. 2021.
Abstract:	Immunosuppression is an important risk factor for leishmaniasis. We assessed the clinical profile, geographic distribution and prevalence of leishmaniasis in patients undergoing immunosuppressive therapy for dermatological, rheumatological or gastroenterological autoimmune diseases. We identified relevant studies in PubMed, EMBASE, Scopus, Web of Science and LILACS on July 3rd, 2018. We included articles that reported at least one case of leishmaniasis in patients undergoing immunosuppressive treatment for dermatological, rheumatological or gastroenterological diseases. Our protocol was registered in PROSPERO (CRD42018103050). We assessed the quality of the included studies with the Joanna Briggs Institute Critical Appraisal Tool. After the removal of duplicates, 5,431 articles were collected and screened. We included 138 articles; the prevalence of leishmaniasis in six methodologically similar studies varied from three to 1,282 cases per 100,000 patients using anti-TNFα drugs, but the results were significantly heterogeneous . Leishmaniasis in patients treated with immunosuppressive drugs is a health problem mostly reported in European countries bordering the Mediterranean Sea; sporadic activities, such as travelling, seem not to be associated with a significant risk of leishmaniasis, although effective control measures must always be observed.
metadata.dc.description.unidade:	Faculdade de Medicina (FMD)
Licença::	(CC BY NC) - This is an open-access article distributed under the terms of the Creative Commons Attribution License.
DOI:	https://doi.org/10.1590/s1678-9946202062028
Appears in Collections:	Artigos publicados em periódicos e afins

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