Title:	A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil
Authors:	Campos, Tatiana Amabile de Gonçalves, Laura Fernandes Magalhães, Kelly Grace Martins, Vicente de Paulo Pappas Júnior, Georgios Joannis Peirano, Gisele Pitout, Johann D. D. Gonçalves, Guilherme Bartolomeu Furlan, João Pedro Rueda Stehling, Eliana Guedes Pitondo-Silva, André
Assunto::	Klebsiella pneumoniae Virulência (Microbiologia) Resistência antimicrobiana
Issue Date:	2018
Publisher:	Frontiers
Citation:	CAMPOS, Tatiana Amabile de et al. A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil. Frontiers in Medicine, v. 5, 265, 2018. DOI: 10.3389/fmed.2018.00265. Disponível em: https://www.frontiersin.org/articles/10.3389/fmed.2018.00265/full. Acesso em: 14 maio 2021.
Abstract:	We report a fatal bacteremia caused by Klebsiella pneumoniae in a 60–70-year-old patient from Brazil. The genomic analysis of three isolates (from blood culture, nasal and anal swabs) showed that the bacteremia was caused by a KPC-2 producing extensively drug-resistant K64-ST11 hypermucousviscous K. pneumoniae (hmKP) harboring several virulence and antimicrobial resistance genes. Although the isolates did not present virulence markers associated with hypervirulent K. pneumoniae (hvKP), they showed invasion and toxicity to epithelial Hep-2 cells; resistance to cell microbicidal mechanisms; and blood and human serum survival, evidencing their pathogenic potential. This study highlights the risk of infection caused by hmKp strains not characterized as hvKP as well as the clinical implications and difficulty of treatment, especially in elderly or immunocompromised patients.
Licença::	© 2018 de Campos, Gonçalves, Magalhães, de Paulo Martins, Pappas Júnior, Peirano, Pitout, Gonçalves, Furlan, Stehling and Pitondo-Silva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI:	https://doi.org/10.3389/fmed.2018.00265
Appears in Collections:	Artigos publicados em periódicos e afins

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