Título:	Parametric evaluation of impedance curve in radiofrequency ablation : a quantitative description of the asymmetry and dynamic variation of impedance in bovine ex vivo model
Autor(es):	Fonseca, Ronei Delfino da Santos, Paulo Roberto Monteiro, Melissa Silva Fernandes, Luciana Alves Campos, Andreia Henrique Borges, Dıbio L. Rosa, Suélia de Siqueira Rodrigues Fleury
Assunto:	Ablação por radiofrequência Carcinoma hepatocelular
Data de publicação:	15-Jan-2021
Editora:	PLoS ONE
Referência:	FONSECA, Ronei Delfino da et al. Parametric evaluation of impedance curve in radiofrequency ablation: a quantitative description of the asymmetry and dynamic variation of impedance in bovine ex vivo model. PLoS ONE, v. 16, n. 1, e0245145, 2021. https://doi.org/ 10.1371/journal.pone.0245145. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245145. Acesso em: 28 maio 2021.
Abstract:	Radiofrequency ablation (RFA) is a treatment for liver tumors with advantages over the traditional treatment of surgical resection. This procedure has the shortest recovery time in early stage tumors. The objective of this study is to parameterize the impedance curve of the RFA procedure in an ex vivo model by defining seven parameters (t1/2, tminimum, tend, Zinitial, Z1/2, Zminimum and Zend). Based on these parameters, three performance indices are defined: one to identify the magnitude of impedance curve asymmetry (δ), one Drop ratio (DR) describing the percentage of impedance decrease until the minimum impedance point is reached, and Ascent Ratio (AR) describing the magnitude of increase in impedance from the minimum impedance point to its maximum point. Fifty ablations were performed in a bovine ex vivo model to measure and evaluate the proposed parameters and performance index. The results show that the groups had an average δ of 29.02%, DR of 22.41%, and AR of 545.33% for RFA without the use of saline or deionized solutions. The saline solution and deionized water-cooled groups indicated the correlation of performance indices δ, DR, and AR with the obtained final ablation volume. Therefore, by controlling these parameters and indices, lower recurrence is achieved.
Licença:	Copyright: © 2021 da Fonseca et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI:	https://doi.org/ 10.1371/journal.pone.0245145
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