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Título : Bioactive bioflavonoids from Platonia insignis (bacuri) residues as added value compounds
Autor : Ribeiro, Dayane C.
Russo, Helena M.
Fraige, Karina
Zeraik, Maria L.
Nogueira, Cláudio R.
Silva, Patrícia B. da
Codo, Ana C.
Calixto, Giovana M. F.
Medeiros, Alexandra I. de
Chorilli, Marlus
Bolzani, Vanderlan S.
metadata.dc.identifier.orcid: http://orcid.org/0000-0002-4961-2353
http://orcid.org/0000-0002-8298-6568
http://orcid.org/0000-0002-0559-8502
http://orcid.org/0000-0003-2267-4754
http://orcid.org/0000-0001-6048-3647
http://orcid.org/0000-0002-6698-0545
http://orcid.org/0000-0001-7019-5825
Assunto:: Frutas tropicais - bacuri
Flavonóides
Fecha de publicación : abr-2021
Editorial : Sociedade Brasileira de Química
Citación : RIBEIRO, Dayane C. et al. Bioactive bioflavonoids from Platonia insignis (bacuri) residues as added value compounds. Journal of the Brazilian Chemical Society, São Paulo, v. 32, n. 4, p. 786-799, abr. 2021. DOI: https://doi.org/10.21577/0103-5053.20200230. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000400786&lng=en&nrm=iso. Acesso em: 12 maio 2021.
Abstract: Platonia insignis fruit, popularly known as bacuri, is traditionally used in folk medicine for its anti-inflammatory and antioxidant properties. Therefore, this study determined the chemical composition and biological activities of the bacuri’s shell and seeds extracts, considered residues from its consumption and industrial uses. Four biflavonoids (GB-2a, GB-1a, morelloflavone, and volkensiflavone) were identified in the extracts by high-performance liquid chromatography-diode array detection (HPLC-DAD), liquid chromatography tandem mass spectrometry (LC-MS/MS), and liquid chromatography-solid phase extraction-nuclear magnetic resonance (LC-SPE-NMR) techniques. Morelloflavone was identified as the main compound in the shell ethyl acetate extract, being responsible for the high in vitro antioxidant (50% effective concentration (EC50) ranging from 8.0-10.5 µg mL−1 in different protocols), anti-glycant (80%), and moderate inhibition of nitric oxide (1.56 µg mL−1 for > 90% cell viability) activities. This extract showed promising in vivo anti-inflammatory activity evaluated through the paw edema protocol after its incorporation into a liquid-crystalline drug carrier system, reducing the edema by up to 31%. The results demonstrated the potential of the fruit for the development of drugs of natural origin and corroborated to add economic value to these discarded residues.
Licença:: (CC BY) - This is an open-access article distributed under the terms of the Creative Commons Attribution License.
DOI: https://doi.org/10.21577/0103-5053.20200230
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