Title:	The association between excess body weight at diagnosis and pediatric leukemia prognosis : a systematic review and meta-analysis
Authors:	Galati, Paula Cristina Ribeiro, Carolina Martins Pereira, Louise Tavares Garcia Amato, Angélica Amorim
Assunto::	Leucemia pediátrica Mortalidade Sobrevivência Sobrepeso Obesidade
Issue Date:	Jan-2022
Publisher:	Elsevier
Citation:	GALATI, Paula Cristina et al. The association between excess body weight at diagnosis and pediatric leukemia prognosis: a systematic review and meta-analysis. Blood Reviews, v. 51, 100870, jan. 2022. DOI: https://doi.org/10.1016/j.blre.2021.100870. Disponível em: https://www.sciencedirect.com/science/article/pii/S0268960X2100076X. Acesso em: 11 fev. 2022.
Abstract:	Obesity affects the prognosis of several types of cancer. However, whether excess body weight is independently associated with adverse outcomes following initial pediatric acute leukemia (AL) treatment is still unclear. We conducted a systematic review and meta-analysis to investigate the impact of overweight/obesity at diagnosis on pediatric AL prognosis following initial treatment by performing an extensive database search up to January 22, 2021. Twenty-three studies were included, providing data for 15689 children with acute lymphoblastic leukemia (ALL) and 2506 children with acute myeloid leukemia (AML). Data from 12 studies were pooled in the meta-analysis. Children with overweight/obesity at diagnosis of ALL had poorer event free-survival (random-effects hazard ratio of 1.44, 95%CI 1.16–1.79, p = 0.0008), but no difference in overall survival (random-effects hazard ratio 1.33, 95%CI 0.77–2.29, p = 0.31) when compared with healthy-weight children. Children with overweight/obesity at diagnosis of AML had no difference in event-free survival (random-effects hazard ratio of 0.88, 95%CI 0.48–1.59, p = 0.66) or overall survival (random-effects hazard ratio 1.40, 95%CI 0.78–2.49, p = 0.26), when compared with healthy-weight children. This systematic review and meta-analysis indicates that overweight/obesity negatively affects the prognosis of children with ALL. Future studies should address the best approach to consider nutritional status in their management.
Licença::	© 2021 Elsevier Ltd. All rights reserved.
DOI:	https://doi.org/10.1016/j.blre.2021.100870
metadata.dc.relation.publisherversion:	https://www.sciencedirect.com/science/article/pii/S0268960X2100076X
Appears in Collections:	Artigos publicados em periódicos e afins

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