Title:	The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19 : a prospective realworld cohort study
Authors:	Cerqueira, Selma Regina Penha Silva Deps, Patrícia Duarte Cunha, Débora Vilela Bezerra, Natanael Victor Furtunato Barroso, Daniel Holanda Pinheiro, Ana Bárbara Sapienza Pillegi, Gecilmara Salviato Repsold, Taynah Alves Rocha Kurizky, Patricia Shu Collin, Simon M. Gomes, Ciro Martins
metadata.dc.identifier.orcid:	https://orcid.org/ 0000-0002-3188-4131 https://orcid.org/ 0000-0001-7833-552X https://orcid.org/ 0000-0003-4128-1593 https://orcid.org/ 0000-0002-2766-3141 https://orcid.org/ 0000-0003-0054-7754 https://orcid.org/ 0000-0002-3220-0838 https://orcid.org/ 0000-0002-3220-0838 https://orcid.org/ 0000-0002-5759-2727 https://orcid.org/ 0000-0002-1239-1681 https://orcid.org/ 0000-0002-3069-6884
Assunto::	Hanseníase Covid-19
Issue Date:	28-Jul-2021
Publisher:	Plos
Citation:	CERQUEIRA, Selma Regina Penha Silva et al. The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: a prospective realworld cohort study. PLoS Neglected Tropical Diseases, v. 15, n. 7, e0009635, 2021. DOI: https://doi.org/10.1371/journal.pntd.0009635. Disponível em: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0009635. Acesso em: 16 maio 2022.
Abstract:	Background Protective effects of Bacillus Calmette–Gue´rin (BCG) vaccination and clofazimine and dapsone treatment against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported. Patients at risk for leprosy represent an interesting model for assessing the effects of these therapies on the occurrence and severity of coronavirus disease 2019 (COVID-19). We assessed the influence of leprosy-related variables in the occurrence and severity of COVID-19. Methodology/Principal findings We performed a 14-month prospective real-world cohort study in which the main risk factor was 2 previous vaccinations with BCG and the main outcome was COVID-19 detection by reverse transcription polymerase chain reaction (RT-PCR). A Cox proportional hazards model was used. Among the 406 included patients, 113 were diagnosed with leprosy. During follow-up, 69 (16.99%) patients contracted COVID-19. Survival analysis showed that leprosy was associated with COVID-19 (p<0.001), but multivariate analysis showed that only COVID-19-positive household contacts (hazard ratio (HR) = 8.04; 95% CI = 4.93– 13.11) and diabetes mellitus (HR = 2.06; 95% CI = 1.04–4.06) were significant risk factors for COVID-19. Conclusions/Significance Leprosy patients are vulnerable to COVID-19 because they have more frequent contact with SARS-CoV-2-infected patients, possibly due to social and economic limitations. Our model showed that the use of corticosteroids, thalidomide, pentoxifylline, clofazimine, or dapsone or BCG vaccination did not affect the occurrence or severity of COVID-19.
metadata.dc.description.unidade:	Faculdade de Medicina (FMD)
Licença::	Copyright: © 2021 Cerqueira et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI:	https://doi.org/10.1371/journal.pntd.0009635
Appears in Collections:	Artigos publicados em periódicos e afins UnB - Covid-19

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