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Título: Organic beet leaves and stalk juice attenuates the glutathione peroxidase increase induced by high-fat meal in dyslipidemic patients : a pilot double-blind, randomized, controlled trial
Autor(es): Oliveira, Amanda Cristine de
Gomes, Anna Paula Oliveira
Rodrigues, Lorena Charife
Cunha, Raisa da Silva
Serra, Thaís Martins
Schincaglia, Raquel Machado
Silva, Marina Alves Coelho
Horst, Maria Aderuza
Rostagno, Maurício Ariel
Magalhães, Kelly Grace
Cunha, Luiz Carlos
Botelho, Patrícia Borges
ORCID: https://orcid.org/0000-0002-8869-5198
https://orcid.org/0000-0003-4325-7730
https://orcid.org/0000-0002-6249-8946
https://orcid.org/0000-0003-1763-5697
https://orcid.org/0000-0002-7435-5272
https://orcid.org/0000-0001-8909-3757
Assunto: Antioxidantes
Polifenóis
Data de publicação: 2022
Editora: MDPI
Referência: OLIVEIRA, Amanda Cristine de et al. Organic beet leaves and stalk juice attenuates the glutathione peroxidase increase induced by high-fat meal in dyslipidemic patients: a pilot double-blind, randomized, controlled trial. Applied Sciences, v. 12, n. 4, 1973, 2022. DOI: https://doi.org/10.3390/app12041973. Disponível em: https://www.mdpi.com/2076-3417/12/4/1973. Acesso em: 2 jun. 2022.
Abstract: The beet, including the leaves and stalk (BLS), is a vegetable with great antioxidant potential. The aim of this study was to evaluate the differences in the nutritional composition and the concentration of total phenolics between the organic and conventional BLS and to verify whether the ingestion of an organic BLS juice containing different concentrations of polyphenols modulated some biomarkers of oxidative stress after the ingestion of a high-fat meal in individuals with dyslipidemia. A controlled, randomized, double-blind, crossover clinical trial with a washout period of 1 week was carried out. A 12-h fasting blood sample was collected. Afterward, the participants consumed a high-fat meal, followed by the ingestion of a placebo or one of the organic BLS juices containing either 32.0 or 77.5 mg/100 mL of polyphenols. Blood samples were obtained 30, 60, 120 and 180 min after the first blood collection. The composition analysis showed that organic BLS had a better nutritional composition than conventional ones. The high-fat meal induced postprandial hypertriglyceridemia after 120 min (p < 0.001) and increased the concentration of malondialdehyde after 30 min (p < 0.001). In addition, there was a significant increase in GPx in 30 min (p = 0.026). This increase was attenuated in the group that received the highest dose of polyphenols when compared with the placebo after 30 min (p = 0.045). Therefore, the organic BLS juice containing 77.5 mg of polyphenols was efficient at modulating one of the postprandial mechanisms of enzymatic antioxidant protection in individuals with dyslipidemia.
Licença: (CC BY)
DOI: https://doi.org/10.3390/app12041973
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