Título:	Does the use of natural products for endodontic therapy in primary teeth have sufficient evidence for clinical practice? : a scoping review
Autor(es):	Vitali, Filipe Colombo Andrada, Ana Cristina Cardoso, Helhen Cristina da Luz Xavier-Junior, Gesner Francisco Teixeira, Cleonice da Silveira Salles, Loise Pedrosa Lia, Erica Negrini Massignan, Carla
Assunto:	Endodontia Dentes decíduos Pulpa
Data de publicação:	19-Jul-2022
Editora:	Springer Nature
Referência:	VITALI, Filipe Colombo et al. Does the use of natural products for endodontic therapy in primary teeth have sufficient evidence for clinical practice?: a scoping review. Clinical Oral Investigations, 2022. DOI 10.1007/s00784-022-04633-4. Disponível em: https://link.springer.com/article/10.1007/s00784-022-04633-4. Acesso em: 23 ago 2022.
Abstract:	Objectives The use of natural products for pulp therapy has experienced a remarkable advancement in recent years. The aim was to provide a critical appraisal of the safety and efcacy of natural products for endodontic therapy in primary teeth and verify whether their uses in clinical practice have sufcient evidence. Materials and methods Two reviewers searched ten databases (Cochrane, DOSS, Embase, Google Scholar, LILACS, OpenGrey, Proquest, PubMed, Scopus, and Web of Science) until January 2022, identifying references that evaluated the safety and efcacy of the use of natural products for endodontic therapy in primary teeth. Cohort, randomized, and non-randomized clinical trials were included. Results A total of 3583 references were initially identifed. From the 63 studies retrieved for full-text reading, 37 fulflled the selection criteria and were included in the qualitative analysis. The studies investigated 19 natural products for pulpotomy medicament, irrigating solution, intracanal medication, and root canal flling material. Most studies showed similar eficacy of natural products and their control groups; however, many methodological biases and concerns about the safety and eficacy of natural products were identifed, questioning their clinical applicability. Conclusions The included studies provided insufcient evidence to support safe and efective clinical application of natural products for endodontic therapy in primary teeth. Future well-designed studies with representative samples are needed to support the use of natural products for endodontic therapy in primary teeth. Clinical relevance. The use of natural products for endodontic therapy in primary teeth requires caution by clinicians, due to the insufcient available evidence.
DOI:	https://doi.org/10.1007/s00784-022-04633-4
Publicação associada:	https://link.springer.com/article/10.1007/s00784-022-04633-4
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