Skip navigation
Veuillez utiliser cette adresse pour citer ce document : http://repositorio.unb.br/handle/10482/44816
Fichier(s) constituant ce document :
Il n'y a pas de fichiers associés à ce document.
Titre: Organometallic gold (III) and platinum (II) complexes with thiosemicarbazone : structural behavior, anticancer activity, and molecular docking
Auteur(s): Almeida, Carolane de Macêdo
Marcon, Pedro Henrique Salgado
Nascimento, Erica Cristina Moreno
Martins, João Batista Lopes
Chagas, Marcio A. S.
Fujimori, Mahmi
Marchi, Patrícia Gelli Feres De
França, Eduardo L.
Honorio-França, Adenilda C.
Gatto, Claudia Cristina
metadata.dc.contributor.email: mailto:ccgatto@unb.br
metadata.dc.identifier.orcid: https://orcid.org/0000-0002-9531-6432
https://orcid.org/0000-0001-9950-1128
https://orcid.org/0000-0003-1365-177X
https://orcid.org/0000-0001-8677-3239
https://orcid.org/0000-0003-0763-6514
https://orcid.org/0000-0002-1646-8738
https://orcid.org/0000-0001-7940-4478
https://orcid.org/0000-0002-1854-5397
https://orcid.org/0000-0002-0452-9804
https://orcid.org/0000-0002-3736-6861
Assunto:: Atividade anticâncer
Complexos organometálicos
Tiossemicarbazona
Date de publication: 30-mai-2022
Editeur: Wiley
Référence bibliographique: ALMEIDA, Carolane M. et al. Organometallic gold (III) and platinum (II) complexes with thiosemicarbazone: structural behavior, anticancer activity, and molecular docking. Applied Organometallic Chemistry, v. 26, n. 8, art. e6761, ago. 2022. DOI 10.1002/aoc.6761. Disponível em: https://onlinelibrary.wiley.com/journal/10990739. Acesso em: 14 set. 2022.
Abstract: This study reports the synthesis and characterization of two new organometallic Au (III) and Pt (II) complexes with 2-acetylthiophene-N(3)- methylthiosemicarbazone (HL). The characterization of the compounds was performed by single-crystal X-ray diffraction and spectroscopic techniques (Fourier transform infrared (FT-IR), UV–Vis, electrospray ionization (ESI)(+)-mass spectrometry (MS), and nuclear magnetic resonance (NMR)). The MS data indicated the presence in the solution of the molecular ion [H2L]+ and characteristic fragmentations of the ligand. The thiosemicarbazone is coordinated to the Au (III) and Pt (II) in tridentate mode through the CNS chelating system. The two metal atoms show a distorted square geometry including chloride ion or triphenylphosphine to complete the coordination sphere. The 3D Hirshfeld surface and the 2D fingerprint results were analyzed quantitatively to verify interactions upon the molecular packing. The biological activity of the free thiosemicarbazone and their complexes have been evaluated against the MCF-7 human cancer cell line. Molecular docking was used to predict the inhibitory activity of the compounds.
metadata.dc.description.unidade: Instituto de Química (IQ)
DOI: https://doi.org/10.1002/aoc.6761
Collection(s) :Artigos publicados em periódicos e afins

Affichage détaillé " class="statisticsLink btn btn-primary" href="/jspui/handle/10482/44816/statistics">



Tous les documents dans DSpace sont protégés par copyright, avec tous droits réservés.