Skip navigation
Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.unb.br/handle/10482/45072
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
ARTIGO_PaternalResistanceTraining.pdf1,86 MBAdobe PDFVisualizar/Abrir
Título : Paternal resistance training induced modifications in the left ventricle proteome independent of offspring diet
Autor : Sousa Neto, Ivo Vieira de
Tibana, Ramires Alsamir
Prestes, Jonato
Silva, Leonardo Gomes de Oliveira da
Almeida, Jeeser Alves
Franco, Octavio Luiz
Oliveira, Edilamar Menezes de
Voltarelli, Fabricio Azevedo
Durigan, João Luiz Quaglioti
Sousa, Marcelo Valle de
Ricart, Carlos André O.
Botelho, Katyelle
Castro, Mariana S
Fontes, Wagner
Marqueti, Rita de Cassia
metadata.dc.contributor.email: mailto:ivoneto04@hotmail.com
mailto:marqueti@gmail.com
metadata.dc.identifier.orcid: https://orcid.org/0000-0002-1479-5866
https://orcid.org/0000-0003-0399-8817
https://orcid.org/0000-0002-3409-8005
https://orcid.org/0000-0001-9546-0525
https://orcid.org/0000-0002-7101-312X
https://orcid.org/0000-0002-8077-8941
https://orcid.org/0000-0002-7511-5289
https://orcid.org/0000-0001-5140-8573
https://orcid.org/0000-0001-9126-3882
Assunto:: Herança genética
Obesidade
Homens - saúde e higiene
Epigenética
Fecha de publicación : 4-may-2020
Citación : SOUSA NETO, Ivo Vieira de et al. Paternal resistance training induced modifications in the left ventricle proteome independent of offspring diet. Oxidative Medicine and Cellular Longevity, v, 2020 art. 5603580, 2020. DOI 10.1155/2020/5603580. Disponível em: https://www.hindawi.com/journals/omcl/2020/5603580/. Acesso em: 26 out. 2022.
Abstract: Ancestral obesogenic exposure is able to trigger harmful effects in the offspring left ventricle (LV) which could lead to cardiovascular diseases. However, the impact of the father’s lifestyle on the offspring LV is largely unexplored. The aim of this study was to investigate the effects of 8 weeks of paternal resistance training (RT) on the offspring left ventricle (LV) proteome exposed to control or high-fat (HF) diet. Wistar rats were randomly divided into two groups: sedentary fathers and trained fathers (8 weeks, 3 times per week with weights secured to the animals’ tails). The offspring were obtained by mating with sedentary females. Upon weaning, male offspring were divided into 4 groups (5 animals per group): offspring from sedentary fathers, exposed to control diet (SFO-C); offspring from trained fathers, exposed to control diet (TFO-C); offspring from sedentary fathers, exposed to high-fat diet (SFO-HF); and offspring from trained fathers, exposed to highfat diet (TFO-HF). The LC-MS/MS analysis revealed 537 regulated proteins among groups. Offspring exposure to HF diet caused reduction in the abundance levels of proteins related to cell component organization, metabolic processes, and transport. Proteins related to antioxidant activity, transport, and transcription regulation were increased in TFO-C and TFO-HF as compared with the SFO-C and SFO-HF groups. Paternal RT demonstrated to be an important intervention capable of inducing significant effects on the LV proteome regardless of offspring diet due to the increase of proteins involved into LV homeostasis maintenance. This study contributes to a better understanding of the molecular aspects involved in transgenerational inheritance.
Licença:: Oxidative Medicine and Cellular Longevity - This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte:https://www.hindawi.com/journals/omcl/guidelines/. Acesso em: 26 out. 2022.
DOI: https://doi.org/10.1155/2020/5603580
Aparece en las colecciones: Artigos publicados em periódicos e afins

Mostrar el registro Dublin Core completo del ítem " class="statisticsLink btn btn-primary" href="/jspui/handle/10482/45072/statistics">



Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.