Skip navigation
Veuillez utiliser cette adresse pour citer ce document : http://repositorio.unb.br/handle/10482/46410
Fichier(s) constituant ce document :
Il n'y a pas de fichiers associés à ce document.
Titre: Innovative treatments for epilepsy : venom peptides, cannabinoids, and neurostimulation
Auteur(s): Lima, Larissa Silva de
Loyola, Vinícius
Bicca, João Victor Montenegro Luzardo
Faro, Lucas
Vale, Camilla Lepesqueur Costa
Denucci, Bruna Lotufo
Mortari, Márcia Renata
metadata.dc.contributor.email: mailto:mmortari@unb.br
metadata.dc.identifier.orcid: https://orcid.org/0000-0002-7050-5560
https://orcid.org/0000-0002-6849-6001
Assunto:: Epilepsia
Neuroestimulação
Canabidiol
Fármacos antiepilépticos
Date de publication: 7-aoû-2022
Editeur: Wiley
Référence bibliographique: LIMA, Larissa Silva de et. al. Innovative treatments for epilepsy: venom peptides, cannabinoids, and neurostimulation. Journal of Neuroscience Research, v. 100, n. 11, p. 1969-1986, nov. 2022. DOI https://doi.org/10.1002/jnr.25114. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/jnr.25114. Acesso em: 28 ago. 2023.
Abstract: Antiepileptic drugs have been successfully treating epilepsy and providing individuals sustained seizure freedom. However, about 30% of the patients with epilepsy present drug resistance, which means they are not responsive to the pharmacological treatment. Considering this, it becomes extremely relevant to pursue alternative therapeutic approaches, in order to provide appropriate treatment for those patients and also improve their quality of life. In the light of that, this review aims to discuss some innovative options for the treatment of epilepsy, which are currently under investigation, addressing strategies that go from therapeutic compounds to clinical procedures. For instance, peptides derived from animal venoms, such as wasps, spiders, and scorpions, demonstrate to be promising antiepileptic molecules, acting on a variety of targets. Other options are cannabinoids and compounds that modulate the endocannabinoid system, since it is now known that this network is involved in the pathophysiology of epilepsy. Furthermore, neurostimulation is another strategy, being an alternative clinical procedure for drug-resistant patients who are not eligible for palliative surgeries.
metadata.dc.description.unidade: Instituto de Ciências Biológicas (IB)
Departamento de Ciências Fisiológicas (IB CFS)
DOI: https://doi.org/10.1002/jnr.25114
metadata.dc.relation.publisherversion: https://onlinelibrary.wiley.com/doi/10.1002/jnr.25114
Agência financiadora: UnB - Edital DPI/DPG n. 02/2022
Collection(s) :Artigos publicados em periódicos e afins

Affichage détaillé " class="statisticsLink btn btn-primary" href="/jspui/handle/10482/46410/statistics">



Tous les documents dans DSpace sont protégés par copyright, avec tous droits réservés.