Title:	Development and validation of analytical method for identification of new psychoactive substances using linear retention indexes and gas chromatography-mass spectrometry
Authors:	Zacca, Jorge Jardim Giudice, Gabriella Hamú Souza, Mônica P. Caldas, Luíza N. B. Vieira, Maurício L. Machado, Ângelo Henirque de Lira
metadata.dc.contributor.affiliation:	Brazilian Federal Police, National Institute of Criminalistics Brazilian Health Regulatory Agency University of Brasília, Institute of Chemistry Brazilian Federal Police, National Institute of Criminalistics Brazilian Federal Police, National Institute of Criminalistics Brazilian Federal Police, National Institute of Criminalistics University of Brasília, Institute of Chemistry
Assunto::	Cromatografia gasosa Espectrometria de massa Substâncias psicoativas
Issue Date:	2021
Publisher:	Elsevier B.V.
Citation:	ZACCA, Jorge J. et al. Development and validation of analytical method for identification of new psychoactive substances using linear retention indexes and gas chromatography-mass spectrometry. Journal of Chromatography A, [S. l.], v. 1636, 461783, 11 jan. 2021. DOI: https://doi.org/10.1016/j.chroma.2020.461783
Abstract:	New Psychoactive Substances (NPS) are quickly developing to evade legislation, posing unprecedented challenges to public health and law enforcement authorities around the world. The aim of this work was to develop and validate a simple and reliable non-target gas chromatography/mass spectrometry (GC/MS) analytical method based on linear retention indexes for the expeditious identification of NPS without the need of analytical standards. The method was optimized and validated for 22 different drugs covering ten categories: phenethylamines (amphetamine, MDMA, methamphetamine, 25C–NBOMe, 2-FA, 5-MAPB), “classic” drugs (cocaine, ephedrine, THC, heroine), synthetic cannabinoids (JWH-081, AM-2201, JWH-210, MAM-2201), piperazines (o-CPP, p-CPP), tryptamines (5-MeO-MiPT), synthetic cathinones (N ethylpentylone), synthetic opioids (U-47700), aminoindanes (5-IAI), plant-based substances (Salvinorin-A) and “other” (methiopropamine). Three figures of merit (Selectivity, Precision and Robustness) were eval uated with retention index confidence intervals ranging from 0.5 to 20.6 i.u. and relative standard de viations in the range of 0.003% to 0.027% (repeatability) and 0.02% to 0.29% (intermediate precision). A general equation for estimating linear retention index variation as a function of retention time tolerance has been derived. This result in combination with a 26−3 III fractional factorial design allowed to conclude column polarity to be only statistically relevant factor as compared to gas flow, split ratio, injection tem perature, temperature program offset and column brand.
metadata.dc.description.unidade:	Instituto de Química (IQ)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Química
DOI:	https://doi.org/10.1016/j.chroma.2020.461783
metadata.dc.relation.publisherversion:	https://www.sciencedirect.com/science/article/pii/S0021967320310578?via%3Dihub
Appears in Collections:	Artigos publicados em periódicos e afins

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