Título:	Age differences in naloxone reversibility of electroacupuncture on the jaw opening reflex in rats
Autor(es):	Yamashita, Hiromi Zeredo, Jorge Luis Lopes Toda, Kazuo
ORCID:	https://orcid.org/0000-0002-2850-0731 https://orcid.org/0000-0003-0338-5850 https://orcid.org/0000-0002-8848-8017
Afiliação do autor:	Nagasaki University, Institute of Biomedical Sciences, Forensic Dental Science University of Brasilia, Ceilandia Campus, Graduate Program in Health Science and Technolog Nagasaki University, Institute of Biomedical Sciences, Integrative Sensory Physiology
Assunto:	Eletroacupuntura Analgesia Mandíbula
Data de publicação:	31-Ago-2021
Editora:	Medical Association of Pharmacopuncture Institute
Referência:	YAMASHITA, Hiromi; ZEREDO, Jorge Luis Lopes; TODA, Kazuo. Age differences in naloxone reversibility of electroacupuncture on the jaw opening reflex in rats. Journal of Acupuncture and Meridian Studies, [S.l.], v. 14, n. 4, 31 ago 2021. Disponível em: https://doi.org/10.51507/j.jams.2021.14.4.167. Acesso em: 20 mar 2024.
Abstract:	Background: Electroacupuncture is one of the most popular physical treatments for clinical pain, but the potential influence of a patient’s age on the effectiveness of electroacupuncture treatment has not been clearly established. Objectives: The present study aimed to detect a potential difference in electroacupuncture- induced analgesia between juvenile and adult rats. Methods: In this study, we investigated the effects of electroacupuncture treatment on the nociceptive jaw-opening reflex evoked by tooth-pulp stimulation in juvenile and adult rats. Results: Our results showed there were age differences in electroacupuncture-induced analgesic effects in rats, especially with naloxone antagonization. The ratio of naloxonereversibility against electroacupuncture analgesia was greater in adult rats than in juvenile rats. Conclusion: These results suggest that electroacupuncture analgesia is produced mainly by the non-opioid system in juvenile rats and by the opioid system in adult rats.
Unidade Acadêmica:	Faculdade UnB Ceilândia (FCE) Colegiado de Bases Biológicas e da Saúde (FCE-BASES)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde
Licença:	(CC BY NC) This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI:	https://doi.org/10.51507/j.jams.2021.14.4.167
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