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Title: Acute effects of the consumption of passiflora setacea juice on metabolic risk factors and gene expression profile in humans
Authors: Duarte, Isabella de Araújo Esteves
Milenkovic, Dragan
Borges, Tatiana Karla dos Santos Borges
Rosa, Artur Jordão de Magalhães
Morand, Cristine
Oliveira, Livia de Lacerda
Costa, Ana Maria
metadata.dc.identifier.orcid: https://orcid.org/0000-0001-6276-3060
https://orcid.org/0000-0001-6353-0912
https://orcid.org/0000-0002-7015-9207
https://orcid.org/0000-0003-4456-7802
metadata.dc.contributor.affiliation: Universidade de Brasília, Campus Universitário Darcy Ribeiro, College of Health Sciences, Postgraduate Program in Human Nutrition
UNH, INRAE, Université Clermont Auvergne, Unité de Nutrition Humaine
University of California Davis, School of Medicine, Division of Cardiovascular Medicine, Department of Internal Medicine.
University of Brasilia, Faculty of Medicine, Laboratory of Cellular Immunology
Embrapa Cerrados, Laboratory of Food Science
UNH, INRAE, Université Clermont Auvergne, Unité de Nutrition Humaine
Universidade de Brasília, Campus Universitário Darcy Ribeiro, College of Health Sciences, Postgraduate Program in Human Nutrition
Embrapa Cerrados, Laboratory of Food Science
Assunto:: Atividade anti-inflamatória
Maracujá - aspectos genéticos
Issue Date: 16-Apr-2020
Publisher: MDPI
Citation: DUARTE, Isabella de Araújo Esteves et al. Acute effects of the consumption of passiflora setacea juice on metabolic risk factors and gene expression profile in humans. Nutrients, [S.l.], v. 12, n. 4, 16 abril 2020. Disponível em: https://www.mdpi.com/2072-6643/12/4/1104. Acesso em: 19 mar 2024.
Abstract: Background: Passiflora setacea (PS) is a passionfruit variety of the Brazilian savannah and is a rich source of plant food bioactives with potential anti-inflammatory activity. This study aimed to investigate the effect of an acute intake of PS juice upon inflammation, metabolic parameters, and gene expression on circulating immune cells in humans. Methods: Overweight male volunteers (n = 12) were enrolled in two double-blind placebo-controlled studies. Blood samples were collected from fasting volunteers 3 h after the consumption of 250 mL of PS juice or placebo (PB). Metabolic parameters (insulin, glucose, total cholesterol, high-density lipoprotein (LDL), high-density lipoprotein (HDL), and total triglycerides) and circulating cytokines were evaluated (study 1). Peripheral blood mononuclear cell (PBMC) from the same subjects were isolated and RNA was extracted for transcriptomic analyses using microarrays (study 2). Results: Insulin and homeostatic model assessment for insulin resistance (HOMA-IR) levels decreased statistically after the PS juice intake, whereas HDL level increased significantly. Interleukin (IL)-17A level increased after placebo consumption, whereas its level remained unchanged after PS juice consumption. Nutrigenomic analyses revealed 1327 differentially expressed genes after PS consumption, with modulated genes involved in processes such as inflammation, cell adhesion, or cytokine–cytokine receptor. Conclusion: Taken together, these clinical results support the hypothesis that PS consumption may help the prevention of cardiometabolic diseases.
metadata.dc.description.unidade: Faculdade de Ciências da Saúde (FS)
metadata.dc.description.ppg: Programa de Pós-Graduação em Nutrição Humana
Licença:: ©2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DOI: https://doi.org/10.3390/nu12041104
Appears in Collections:Artigos publicados em periódicos e afins

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