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dc.contributor.authorRomeiro, Luiz Antonio Soares-
dc.contributor.authorNunes, Jéssica Larissa da Costa-
dc.contributor.authorMiranda, Camila de Oliveira-
dc.contributor.authorCardoso, Gabriella Simões Heyn Roth-
dc.contributor.authorOliveira, Andressa Souza de-
dc.contributor.authorGandini, Annachiara-
dc.contributor.authorKobrlova, Tereza-
dc.contributor.authorSoukup, Ondrej-
dc.contributor.authorRossi, Michele-
dc.contributor.authorSenger, Johanna-
dc.contributor.authorJung, Manfred-
dc.contributor.authorGervasoni, Silvia-
dc.contributor.authorVistoli, Giulio-
dc.contributor.authorPetralla, Sabrina-
dc.contributor.authorMassenzio, Francesca-
dc.contributor.authorMonti, Barbara-
dc.contributor.authorBolognesi, Maria Laura-
dc.date.accessioned2024-06-05T16:09:23Z-
dc.date.available2024-06-05T16:09:23Z-
dc.date.issued2019-03-29-
dc.identifier.citationROMEIRO, Luiz Antonio Soares et al. Novel sustainable-by-design HDAC inhibitors for the treatment of Alzheimer’s disease. ACS Medicinal Chemistry Letters, v. 10, n. 4, 671–676, 2019. DOI: 10.1021/acsmedchemlett.9b00071.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/48163-
dc.language.isoengpt_BR
dc.publisherAmerican Chemical Societypt_BR
dc.rightsAcesso Restritopt_BR
dc.titleNovel sustainable-by-design HDAC inhibitors for the treatment of Alzheimer’s diseasept_BR
dc.typeArtigopt_BR
dc.subject.keywordAlzheimer, Doença dept_BR
dc.subject.keywordCastanha de cajupt_BR
dc.subject.keywordMedicamentospt_BR
dc.subject.keywordImunomodulaçãopt_BR
dc.identifier.doi10.1021/acsmedchemlett.9b00071pt_BR
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00071pt_BR
dc.description.abstract1Alzheimer’s disease (AD) represents a global problem, with an estimation of the majority of dementia patients in low- and middle-income countries by 2050. Thus, the development of sustainable drugs has attracted much attention in recent years. In light of this, taking inspiration from the HDAC inhibitor vorinostat (1), we develop the first HDAC inhibitors derived from cashew nut shell liquid (CNSL), an inexpensive agro-food waste material. CNSL derivatives 8 and 9 display a HDAC inhibitory profile similar to 1, together with a more promising safety for 9 compared to 1. Moreover, both compounds and particularly 9 were able to effectively modulate glial cell-induced inflammation and to revert the pro-inflammatory phenotype. All these results demonstrate that the use of inexpensive food waste materials could be successfully applied for the development of accessible and sustainable drug candidates for the treatment of AD.pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-2888-9636pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-6361-7716pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-3939-5172pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-1289-5361pt_BR
dc.contributor.affiliationUniversity of Brasília, Health Sciences Faculty, Department of Pharmacypt_BR
dc.contributor.affiliationCatholic University of Brasilia, LADETERpt_BR
dc.contributor.affiliationUniversity of Brasília, Health Sciences Faculty, Department of Pharmacypt_BR
dc.contributor.affiliationUniversity of Brasília, Health Sciences Faculty, Department of Pharmacypt_BR
dc.contributor.affiliationUniversity of Brasília, Health Sciences Faculty, Department of Pharmacypt_BR
dc.contributor.affiliationUniversity of Brasília, Health Sciences Faculty, Department of Pharmacypt_BR
dc.contributor.affiliationAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnologypt_BR
dc.contributor.affiliationScuola Internazionale Superiore di Studi Avanzati (SISSA), Department of Neuroscience, Laboratory of Prion Biologypt_BR
dc.contributor.affiliationUniversity Hospital Hradec Kralove, Biomedical Research Centerpt_BR
dc.contributor.affiliationUniversity Hospital Hradec Kralove, Biomedical Research Centerpt_BR
dc.contributor.affiliationAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnologypt_BR
dc.contributor.affiliationUniversity of Freiburg, Institute of Pharmaceutical Sciencespt_BR
dc.contributor.affiliationUniversity of Freiburg, Institute of Pharmaceutical Sciencespt_BR
dc.contributor.affiliationUniversity of Milan, Department of Pharmaceutical Sciencept_BR
dc.contributor.affiliationUniversity of Milan, Department of Pharmaceutical Sciencept_BR
dc.contributor.affiliationAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnologypt_BR
dc.contributor.affiliationAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnologypt_BR
dc.contributor.affiliationAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnologypt_BR
dc.contributor.affiliationAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnologypt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
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