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Title: Novel sustainable-by-design HDAC inhibitors for the treatment of Alzheimer’s disease
Authors: Romeiro, Luiz Antonio Soares
Nunes, Jéssica Larissa da Costa
Miranda, Camila de Oliveira
Cardoso, Gabriella Simões Heyn Roth
Oliveira, Andressa Souza de
Gandini, Annachiara
Kobrlova, Tereza
Soukup, Ondrej
Rossi, Michele
Senger, Johanna
Jung, Manfred
Gervasoni, Silvia
Vistoli, Giulio
Petralla, Sabrina
Massenzio, Francesca
Monti, Barbara
Bolognesi, Maria Laura
metadata.dc.identifier.orcid: http://orcid.org/0000-0002-2888-9636
http://orcid.org/0000-0002-6361-7716
http://orcid.org/0000-0002-3939-5172
http://orcid.org/0000-0002-1289-5361
metadata.dc.contributor.affiliation: University of Brasília, Health Sciences Faculty, Department of Pharmacy
Catholic University of Brasilia, LADETER
University of Brasília, Health Sciences Faculty, Department of Pharmacy
University of Brasília, Health Sciences Faculty, Department of Pharmacy
University of Brasília, Health Sciences Faculty, Department of Pharmacy
University of Brasília, Health Sciences Faculty, Department of Pharmacy
Alma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology
Scuola Internazionale Superiore di Studi Avanzati (SISSA), Department of Neuroscience, Laboratory of Prion Biology
University Hospital Hradec Kralove, Biomedical Research Center
University Hospital Hradec Kralove, Biomedical Research Center
Alma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology
University of Freiburg, Institute of Pharmaceutical Sciences
University of Freiburg, Institute of Pharmaceutical Sciences
University of Milan, Department of Pharmaceutical Science
University of Milan, Department of Pharmaceutical Science
Alma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology
Alma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology
Alma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology
Alma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology
Assunto:: Alzheimer, Doença de
Castanha de caju
Medicamentos
Imunomodulação
Issue Date: 29-Mar-2019
Publisher: American Chemical Society
Citation: ROMEIRO, Luiz Antonio Soares et al. Novel sustainable-by-design HDAC inhibitors for the treatment of Alzheimer’s disease. ACS Medicinal Chemistry Letters, v. 10, n. 4, 671–676, 2019. DOI: 10.1021/acsmedchemlett.9b00071.
Abstract: Alzheimer’s disease (AD) represents a global problem, with an estimation of the majority of dementia patients in low- and middle-income countries by 2050. Thus, the development of sustainable drugs has attracted much attention in recent years. In light of this, taking inspiration from the HDAC inhibitor vorinostat (1), we develop the first HDAC inhibitors derived from cashew nut shell liquid (CNSL), an inexpensive agro-food waste material. CNSL derivatives 8 and 9 display a HDAC inhibitory profile similar to 1, together with a more promising safety for 9 compared to 1. Moreover, both compounds and particularly 9 were able to effectively modulate glial cell-induced inflammation and to revert the pro-inflammatory phenotype. All these results demonstrate that the use of inexpensive food waste materials could be successfully applied for the development of accessible and sustainable drug candidates for the treatment of AD.
metadata.dc.description.unidade: Faculdade de Ciências da Saúde (FS)
Departamento de Farmácia (FS FAR)
DOI: 10.1021/acsmedchemlett.9b00071
metadata.dc.relation.publisherversion: https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00071
Appears in Collections:Artigos publicados em periódicos e afins

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