Título:	Antitumor evaluation of amaryllidaceae alkaloids on cancer cell lines : a literature review
Autor(es):	Paiva, Maykon Jhuly Martins de Nascimento, Guilherme Nobre L do Damasceno, Iangla Araújo de Melo Cunha, Lucas Nordhoff Barcelos Pimentel, Jeremias Emanoel de Sousa Silva, Leda Terezinha Freitas e Castro, Tayslane Dias Silveira, Dâmaris
ORCID:	https://orcid.org/0000-0002-6228-4550 https://orcid.org/0000-0003-4185-0872 https://orcid.org/0000-0003-1281-8566 https://orcid.org/0009-0003-5826-6864 https://orcid.org/0009-0004-2163-1028 https://orcid.org/0000-0002-1909-1286 https://orcid.org/0009-0002-3751-7081 https://orcid.org/0000-0003-1851-5224
Afiliação do autor:	University of Brasília, Faculty of Health Sciences, Laboratory of Natural Products University of Gurupi, Paraíso do Tocantins Federal University of Tocantins, Laboratory of Basic and Health Sciences University of Brasília, Faculty of Health Sciences, Laboratory of Natural Products University of Gurupi, Paraíso do Tocantins University of Gurupi, Paraíso do Tocantins Faculdade de Palmas Federal University of Tocantins, Laboratory of Basic and Health Sciences University of Brasília, Faculty of Health Sciences, Laboratory of Natural Products
Assunto:	Amaryllidaceae Alcalóides Atividade antitumoral Apoptose Angiogênese
Data de publicação:	2024
Editora:	Modestum
Referência:	PAIVA, Maykon Jhuly Martins de et al. Antitumor evaluation of amaryllidaceae alkaloids on cancer cell lines: a literature review. Electronic Journal of General Medicine, [S. l.], v. 21, n. 1, em562, 2024. DOI: https://doi.org/10.29333/ejgm/14040. Disponível em: https://www.ejgm.co.uk/article/antitumor-evaluation-of-amaryllidaceae-alkaloids-on-cancer-cell-lines-a-literature-review-14040. Acesso em: 07 jun. 2024.
Abstract:	Amaryllidaceae alkaloids have attracted significant attention in cancer research for their potential antitumor properties. To date, numerous studies have investigated the effects of these alkaloids on cancer cell lines, but a comprehensive synthesis of the existing evidence through a literature review is warranted. This article presents a comprehensive literature review aimed at evaluating the antitumor effects of amaryllidaceae alkaloids on various cancer cell lines and elucidating the underlying mechanisms of action. A search was conducted in major scientific databases, including Google Scholar, PubMed, Scopus, and Web of Science, to identify relevant studies published between 2013 and 2023. Studies that examined the antitumor effects of amaryllidaceae alkaloids on cancer cell lines were included in the review. Data were extracted, analyzed, and synthesized to provide an in-depth overview of the findings. The alkaloids exhibited potent cytotoxicity and suppressed cell proliferation in a concentration dependent manner. Mechanistic investigations unveiled that amaryllidaceae alkaloids induced apoptosis, cell cycle arrest, and hindered angiogenesis in cancer cells. Moreover, they demonstrated favorable selectivity towards cancer cells, sparing normal cells, suggesting potential as targeted therapies. This literature review consolidates and critically appraises the available evidence on the antitumor effects of amaryllidaceae alkaloids on cancer cell lines. The findings underscore their potential as promising candidates for further exploration in cancer therapeutics. Future preclinical and clinical studies are vital to advance their development and translation into effective anticancer drugs.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS FAR)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências Farmacêuticas
Licença:	© 2024 by Author/s and Licensed by Modestum. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI:	https://doi.org/10.29333/ejgm/14040
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