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Title: Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia
Authors: Siqueira, Elis Regina Lima
Pinheiro, Willie Oliveira
Aquino, Victor Raul Romero
Coelho, Breno Cunha Pinto
Bakuzis, Andris Figueiroa
Azevedo, Ricardo Bentes
Sousa, Marcelo Henrique
Morais, Paulo Cesar
metadata.dc.identifier.orcid: https://orcid.org/0000-0003-3366-106X
https://orcid.org/0000-0002-2137-9588
https://orcid.org/0000-0003-1210-8329
metadata.dc.contributor.affiliation: University of Brasília, Institute of Biological Sciences, Department of Genetics & Morphology
University of Brasília, Faculty of Ceilândia, Green Nanotechnology Group
University of Brasília, Faculty of Ceilândia, Post-Graduation Program in Sciences and Health Technologies
Federal University of Goiás, Institute of Physics
University of Brasília, Institute of Physics
Federal Institute of Brasília
Federal University of Goiás, Institute of Physics
Federal University of Goiás, CNanoMed
University of Brasília, Institute of Biological Sciences, Department of Genetics & Morphology
University of Brasília, Faculty of Ceilândia, Green Nanotechnology Group
University of Brasília, Faculty of Ceilândia, Post-Graduation Program in Sciences and Health Technologies
University of Brasília, Institute of Physics
Catholic University of Brasília
Assunto:: Magnetohipertermia
Nanopartículas magnéticas
Fluidos magnéticos
Temperatura
Issue Date: 12-Aug-2022
Publisher: MDPI
Citation: SIQUEIRA, Elis Regina Lima et al. Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia. Nanomaterials, [S. l.], v. 12, n. 16, 2760, DOI: https://doi.org/10.3390/nano12162760 10.3390/nano12162760. Disponível em: https://www.mdpi.com/2079-4991/12/16/2760
Abstract: This study investigated the fabrication of spherical gold shelled maghemite nanoparticles for use in magnetic hyperthermia (MHT) assays. A maghemite core (14 ± 3 nm) was used to fabricate two samples with different gold thicknesses, which presented gold (g)/maghemite (m) content ratios of 0.0376 and 0.0752. The samples were tested in MHT assays (temperature versus time) with varying frequencies (100–650 kHz) and field amplitudes (9–25 mT). The asymptotic temperatures (T∞) of the aqueous suspensions (40 mg Fe/mL) were found to be in the range of 59–77 ◦C (naked maghemite), 44–58 ◦C (g/m = 0.0376) and 33–51 ◦C (g/m = 0.0752). The MHT data revealed that T∞ could be successful controlled using the gold thickness and cover the range for cell apoptosis, thereby providing a new strategy for the safe use of MHT in practice. The highest SAR (specific absorption rate) value was achieved (75 kW/kg) using the thinner gold shell layer (334 kHz, 17 mT) and was roughly twenty times bigger than the best SAR value that has been reported for similar structures. Moreover, the time that was required to achieve T∞ could be modeled by changing the thermal conductivity of the shell layer and/or the shape/size of the structure. The MHT assays were pioneeringly modeled using a derived equation that was analytically identical to the Box–Lucas method (which was reported as phenomenological).
metadata.dc.description.unidade: Instituto de Ciências Biológicas (IB)
Departamento de Genética e Morfologia (IB GEM)
Faculdade UnB Ceilândia (FCE)
Instituto de Física (IF)
metadata.dc.description.ppg: Programa de Pós-Graduação em Ciências e Tecnologias em Saúde
Licença:: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
DOI: https://doi.org/10.3390/nano12162760 10.3390/nano12162760
Appears in Collections:Artigos publicados em periódicos e afins

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