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dc.contributor.authorAlmo, Manuela Maragno do-
dc.contributor.authorSousa, Isabel Garcia-
dc.contributor.authorOlinto, Vitor Guimarães-
dc.contributor.authorPinhate, Sylvia Barbosa-
dc.contributor.authorJivago, José Luiz de Paula Rôlo-
dc.contributor.authorSousa, Davi Emanuel Ribeiro de-
dc.contributor.authorCastro, Márcio Botelho de-
dc.contributor.authorRubini, Marciano Régis-
dc.contributor.authorMaranhão, Andrea Queiroz-
dc.contributor.authorBrigido, Marcelo Macedo-
dc.date.accessioned2024-10-22T10:57:52Z-
dc.date.available2024-10-22T10:57:52Z-
dc.date.issued2023-11-17-
dc.identifier.citationALMO, Manuela Maragno do et al. Therapeutic effects of Zymomonas mobilis on experimental DSS-Induced colitis mouse model. Microorganisms, [S. l.], v. 11, n. 11, 2023. DOI: https://doi.org/10.3390/microorganisms11112793. Disponível em: https://www.mdpi.com/2076-2607/11/11/2793. Acesso em: 22 out. 2024.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/50649-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleTherapeutic effects of Zymomonas mobilis on experimental DSS-Induced colitis mouse modelpt_BR
dc.typeArtigopt_BR
dc.subject.keywordBactériaspt_BR
dc.subject.keywordColitept_BR
dc.subject.keywordMicrobiotapt_BR
dc.subject.keywordImunomodulaçãopt_BR
dc.subject.keywordProbióticospt_BR
dc.rights.license© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)pt_BR
dc.identifier.doihttps://doi.org/10.3390/microorganisms11112793pt_BR
dc.description.abstract1Zymomonas mobilis, a Gram-negative bacteria observed in some popular beverages, is considered safe and has been studied for its potential therapeutic benefits. In this study, we explored its effects on the inflammatory process, tissue integrity, differential gene expression, and microbiota composition in an experimental dextran sulfate sodium (DSS)-induced colitis model in mice. As a result, Z. mobilis alleviated the symptoms caused by DSS administration, as indicated by reduced weight loss, disease activity index, a significant reduction in the colon weight/length ratio, and histopathological improvement. Also, Z. mobilis could restore the mucosal barrier as well as increase the expression of Muc3 and Ocln genes. An analysis of 16S rRNA sequences showed that Z. mobilis alters gut microbiota, increasing Akkermansia muciniphila abundance and decreasing Escherichia coli. Furthermore, Z. mobilis seems to be involved in potentiating a regulatory phenotype by inducing immunomodulatory genes like Tgfb, Il5, Il10, and Foxp3 and reducing the relative mRNA expression of proinflammatory cytokines TNF, Il6, and Il17. Our data suggest that Z. mobilis could alleviate disease progression and be considered a possible probiotic adjuvant for pathologies of the bowel.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0361-7730pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6326-9803pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1237-0693pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3996-0856pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1946-7191pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7136-7059pt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Medicine Faculty, Molecular Pathology Graduation Programpt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Molecular Biology Graduation Programpt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Molecular Biology Graduation Programpt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciencespt_BR
dc.contributor.affiliationUniversity of Brasilia, Veterinary Pathology Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasilia, Veterinary Pathology Laboratorypt_BR
dc.contributor.affiliationEmbrapa Agroenergy, Laboratory of Genetics and Molecular Biologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biologypt_BR
dc.contributor.affiliationNational Institute of Science and Technology (iii-INCT), Institute for Immunology Investigationpt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biologypt_BR
dc.contributor.affiliationNational Institute of Science and Technology (iii-INCT), Institute for Immunology Investigationpt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
dc.description.unidadeFaculdade de Medicina (FM)pt_BR
dc.description.unidadeFaculdade de Agronomia e Medicina Veterinária (FAV)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Patologia Molecularpt_BR
dc.description.ppgPrograma de Pós-Graduação em Biologia Molecularpt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências Animaispt_BR
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